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Testosterone and Its Bioactive Components Are Associated with Libido and the Metabolic Syndrome in Men

机译：睾酮及其生物活性成分与男性的性欲和代谢综合征有关

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Background: Some evidence has shown that the prevalence of hypoactive sexual desire and erectile dysfunction (ED) is associated with testosterone levels whilst higher levels of testosterone have been reported to increase the frequency of intercourse. Available evidence points towards an etiologic role for hypogonadism in the causation of diabetes, metabolic syndrome (Mets) and sexual dysfunction (SD) even though the exact pathophysiological linkage is yet to be fully elucidated. This study therefore sought to evaluate the impact of testosterone as well as its bioactive components on both the MetS and SD. Method: Diabetic men engaged in a stable heterosexual relationship for at least 2 years were recruited for this study. Participants were at least 18 years and provided an informed and signed consent to partake in this study. Fasting blood samples were taken from the participants for biochemical and hormonal assay. The participants were then evaluated using the Golombok Rust Inventory of Sexual Satisfaction for males (GRISS-M). Metabolic syndrome was assessed using the NCEP-ATP III, IDF and WHO criteria. All data analyses were performed using the SPSS software, version 11.0 systat, Inc. Germany and GraphPad Prism, version 5.0, San Diego California, USA. Results: The mean total, free and bioavailable testosterone as well as SHBG recorded among the participants was 7.10 ± 1.23 ng/ml, 0.10 ± 0.01 ng/ml, 7.01 ± 1.41 ng/ml and 4.33 ± 1.12 nmol/l respectively. Subjects with the MetS showed significantly lower SHBG levels in comparison with subjects without the MetS. Participants with raised triglyceride levels showed significantly lower levels of total, free and bioavailable testosterone when compared to participant without raised triglycerides. Participants with problems of avoidance and infrequency of sexual activity showed significantly lower levels of total, free and bioavailable testosterone when compared to participants without avoidance or infrequency problems. The +SD/+MetS group recorded the lowest SHBG levels. Conclusion: Testosterone and its bioactive components are associated with male libido as well as the metabolic syndrome. Low levels of free and bioavailable testosterone are true determinants of the MetS in men.
机译：背景：有些证据表明，据报道，据报道，睾酮水平的低吸力性欲和勃起功能障碍（ED）的患病率有关，而据报道较高水平的睾酮以增加性交频率。即使尚未完全阐明确切的病理生理联系，可用于糖尿病，代谢综合征（METS）和性功能障碍（SD）的恶作因子在后性发作的证据表明，即使尚未完全阐明。因此，本研究寻求评估睾酮以及其生物活性组分在Mets和SD上的影响。方法：为这项研究招募了令人稳定的异性恋关系，从事稳定的异性恋关系，为这项研究招募了至少2年。与会者至少有18年，并在这项研究中提供了通知和签署的同意。从参与者中取出禁食血液样品进行生化和激素测定。然后使用雄组的性满意度对男性的性满意度进行评估，参与者进行评估（Griss-M）。使用NCEP-ATP III，IDF和世卫组织评估代谢综合征。所有数据分析都是使用SPSS软件，版本11.0 Systat，Inc。德国和GraphPad Prism，5.0版，美国圣地亚哥加利福尼亚州。结果：参与者中记录的平均总数，免费和生物利用睾酮以及SHBG分别记录70±1.23ng / mL，0.10±0.01ng / ml，7.01±1.41ng / ml和4.33±1.12 nmol / L.与Mets的受试者与没有MET的受试者相比，SHBG水平显着降低。与参与者相比，培养的甘油三酯水平的参与者显着降低了总，自由和生物可利用的睾酮，而没有培养的甘油三酯。与参与者相比，参与者避免问题和性活动的少数表现出显着较低的总量，免费和生物可利用的睾酮，而不会避免或不频繁问题。 + SD / + METS组记录了最低的SHBG水平。结论：睾酮及其生物活性成分与雄性性欲以及代谢综合征有关。低水平的自由和生物利用睾酮是男性Mets的真正决定因素。

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