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首页> 外文期刊>African Journal of Biotechnology >Metabolic markers as possible diagnostic tools to distinguish between Gram positive and Gram negative septicaemia in baboons
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Metabolic markers as possible diagnostic tools to distinguish between Gram positive and Gram negative septicaemia in baboons

机译：代谢标记作为可能的诊断工具，以区分狒狒的克阳性和革兰阴性败血症

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Septicemia is a disease with high mortality and morbidity.? Most patients die within 48 h after infection because directed treatment can only start after the bacterium is identified as gram positive or gram negative.? This may take up to 72 h.? Early identification of the causative pathogen can therefore decrease the high mortality rate following infection. The aim was to identify possible metabolic markers of gram positive and gram negative septicemia in appropriately infected baboons.? Ten baboons, anaesthetised with ketamine hydrochloride and pentobarbitone for 24 h, were used in this pilot study.? Blood and urine samples were collected at various intervals during the 24 h.? Four baboons were inoculated with?S. pyogenes?H305 and four with?E. coli?O111:B4. Two baboons served as controls.? Acyl carnitine, amino acids, organic acids, very long chain fatty acids, glucose, pyruvate and lactate were measured in blood plasma and in urine using standardised methods.? No metabolic markers could distinguish between gram positive and gram negative septicemia.? α-Amino-adipic acid, citramalic acid and xanthurenic acid, produced only by bacteria, show promise. Alanine and glycine increased significantly over 24 h and can be used as diagnostic markers and perhaps as markers of disease progression. In conclusion, (in PDF file it is conclusively) metabolites can be used to diagnose septicemia and possibly its progression, but not to distinguish between gram positive and gram negative septicemia.
机译：败血症是一种患有高死亡率和发病率的疾病。大多数患者在感染后48小时内死亡，因为定向治疗只能在细菌被鉴定为克阳性或革兰氏阴性之后。这可能需要72小时。？因此，早期鉴定致病病原体可以降低感染后的高死亡率。目的是在适当感染的狒狒中识别革兰氏阳性和革兰氏阴性败血症的可能代谢标志物。在这项试点研究中使用了用盐酸酮盐和戊巴比妥的氯胺酮麻醉的狒狒，在这项试验研究中使用了氯胺酮和五百溴苯胺。在24小时内以各个间隔收集血液和尿液样品。四个狒狒被接种了。 pyogenes？H305和四有？e。 COLI？O111：B4。两个狒狒担任控制权。？在血浆中测量丙基肉碱，氨基酸，有机酸，非常长的链脂肪酸，葡萄糖，丙酮酸和乳酸，并使用标准化方法在尿液中测量。没有代谢标志物可以区分克阳性和革兰氏阴性遗产病。 α-氨基 - 己二酸，柠檬酸和X硫酸，仅由细菌产生，显示承诺。丙氨酸和甘氨酸在24小时内显着增加，可用作诊断标志物，也许是疾病进展的标志物。总之，（在PDF文件中，它是最终的）代谢物可用于诊断败血症，可能是它的进展，但不能区分革兰氏阳性和革兰氏阴性遗产病。

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