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首页> 外文期刊>American Journal of Analytical Chemistry >Trace Determination of Duloxetine HCl in Formulation and Spiked Human Serum at a Carbon Paste Electrode
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Trace Determination of Duloxetine HCl in Formulation and Spiked Human Serum at a Carbon Paste Electrode

机译：在碳浆料电极中追踪二氟乙胺HCl中的掺入人血清

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The electrochemical behavior of duloxetine HCl (DXT.HCl) at a carbon paste electrode (CPE) was achieved by cyclic voltammetry and a mechanism of its oxidation was reported and illustrated. A sensitive linear sweep and square-wave adsorptive anodic stripping voltammetry methods were described for trace determination of DXT.HCl. Introduction: DXT.HCl, N-methyl-3-(nap-thalen-1- yloxy)-3-(thiophene-2-yl) propan-1-amine hydrochloride is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) originally developed as an antidepressant and is currently recommended for maintenance treatment of major depressive disorder. Methods: Electrochemical behavior was studied using cyclic voltammetric method, and the analytical application was studied using linear sweep and square wave voltammetric methods. Solution pH has been measured by pH meter. Results: The process on the surface of carbon paste electrode was found to be irreversible and diffusion-controlled. The number of proton and electron transferred were calculated. Possible reaction mechanism taking place on the surface of electrode was proposed. Calibration plot constructed using square wave voltammetric technique was used for quantitative analysis in pharmaceutical and human serum samples. Limit of detection (LOD) and limit of quantification (LOQ) were calculated. Conclusions: In the present work, we described the electrochemical behavior of DXT.HCl drug. Two precise linear sweep and square wave adsorptive anodic stripping voltammetry methods have been described for its trace quantitation in pharmaceutical formulation and human serum. The method shows the development of a sensor for selective and sensitive determination of DXT.HCl.
机译：通过环状伏安法实现碳糊电极（CPE）在碳糊电极（CPE）处的电化学行为，并报告并说明其氧化机理。描述了一种敏感的线性扫描和方波吸附性阳极溶出伏安法测定DXT.HCL的痕量测定。 介绍： DXT.HCl，N-甲基-3-（NAP-THALEN-1-酰氧基）-3-（噻吩-2-基）丙烷-1-氨基盐酸盐是一种选择性血清素 - 去甲肾上腺素Reutiake抑制剂（SNRI）最初被开发为抗抑郁药，目前推荐用于治疗主要抑郁症。 方法：使用循环伏安法研究了电化学行为，使用线性扫描和方波伏安法研究了分析应用。溶液pH通过pH计测量。 结果：碳浆料表面的方法被发现是不可逆和扩散控制的。计算质子和电子传递的数量。提出了在电极表面上发生的可能反应机制。使用方波伏安法构造的校准图用于药物和人血清样品中的定量分析。计算检测限（LOD）和量化限制（LOQ）。 结论：在本作工作中，我们描述了DXT.HCL药物的电化学行为。已经描述了两种精确的线性扫描和方波吸附阳极挥发挥发挥发挥发挥发挥发浇弧线方法，用于其在药物制剂和人血清中的痕量定量。该方法显示了用于选择性和敏感的DXT.HCL的传感器的开发。

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