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FTIR-ATR and FT-Raman Spectroscopy for Biochemical Changes in Oral Tissue

机译：FTIR-ATR和FT-拉曼光谱，用于口腔组织的生化变化

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Nowadays, biomedicine development is caused by the necessity of fast premalignant and malignant diagnosis. In the case of cancer, it is important to identify degree of tumor’s malice. We investigated the differences of Fourier Transform Infrared-Attenuated Total Reflection (FTIR-ATR) and FT-Raman spectroscopy between leukoplakia, oral cancer and normal tissues. Human tissue contains many compounds with known absorption spectra in the range of Near Infrared (NIR) spectroscopy. These compounds have a fingerprint region, which permits their characterization. FTIR spectroscopy is a promising diagnostic tool. There is ability to detect skin, cervix, prostate, breast, esophagus, stomach, bladder and oral cancers [1]. Imaging using FTIR microscope allows analysis of biochemical compounds in microregions of biological materials. FTIR microspectroscopy is the perfect technique for tissues and individual cells analysis [1]. It delivers information about biochemistry of cell or tissue samples and has been applied in many areas of medical research [2]. IR absorption spectra of abnormal tissues and normal tissues are compared by lipid (2800 - 3000 cm–1), protein (1500 - 1700 cm–1), and nucleic acids (1000 - 1250 cm–1) regions [2]. One of the mucous membrane lesions of the mouth is leukoplakia. This change has a “fingerprint region” in the range of 900 - 1800 cm–1 [3]. Raman spectroscopy has high potential of medical diagnosis. This method is a molecular specific technique that can be used to develop a fundamental biochemical understanding of tissue physiology and pathology. Both methods are dedicated to screening of preneoplastic and neoplastic tissues and have a potential to reduce morbidity of leucoplakia and oral cancers. Obtained data suggested that these infrared techniques are applicable to biomedical and clinical diagnostics.
机译：如今，生物医学发育是由快速祖先和恶性诊断的必要性引起的。在癌症的情况下，重要的是识别肿瘤的恶意程度。我们调查了傅里叶变换红外衰减的全反射（FTIR-ATR）和FT-拉曼光谱在白细胞，口服癌和正常组织之间的差异。人组织含有许多具有已知吸收光谱的化合物，在近红外（NIR）光谱的范围内。这些化合物具有指纹区域，其允许其表征。 FTIR光谱是一个有前途的诊断工具。有能力检测皮肤，子宫颈，前列腺，乳腺癌，食道，胃，膀胱和口腔癌[1]。使用FTIR显微镜的成像允许分析生物材料的微观原料中的生化化合物。 FTIR MicroSpectroscopy是组织和个体细胞分析的完美技术[1]。它提供有关细胞或组织样本的生物化学的信息，并且已应用于医学研究的许多领域[2]。异常组织和正常组织的IR吸收光谱通过脂质（2800-3000cm-1），蛋白质（1500-1700cm-1）和核酸（1000-1250cm-1）区域进行比较[2]。口腔的粘膜病变之一是白血病。此变化具有900-1800cm-1的范围内的“指纹区域”[3]。拉曼光谱具有高潜力的医学诊断。该方法是一种分子具体技术，可用于开发对组织生理学和病理学的基本生化理解。两种方法都专用于筛选促塑料和肿瘤组织，并具有降低白胶和口腔癌的发病率。获得的数据表明，这些红外技术适用于生物医学和临床诊断。

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