Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

Chioma Don-Lawson; Daniel Okechukwu Nweneka; Reminus Okah; Kingsley J. Orie

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Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

机译：1,1-双（2-氨基甲酰基胍亚胺）呋喃-2-基甲烷的合成，表征和生物活性

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This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, ~(1)H-NMR, ~(13)C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on Escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.

机译：本研究报告了1,1-双（2-氨基甲酰胍亚胺烷烃）呋喃-2-基甲烷，表征和生物活性的合成。第一步涉及糠醛与尿素的偶联，得到1-（（2-氨基甲酰胍亚胺氨基）（Furan-2-基甲基）尿素，随后用更多的乙醇中的尿素回流1小时，得到产物。中间和产品通过GC-MS，IR，〜（1）H-NMR，〜（13）C-NMR。合成化合物1,1-双（2-氨基甲酰基）呋喃-2-基甲烷在大肠杆菌，Salmomellyphi和Salmomellyphi和枯草芽孢杆菌在不同程度上并且在金黄色葡萄球菌上无活性。生物活性部分和药理活动的潜在未来在新型药物发展中证明了糠醛衍生物的效力。

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《American Journal of Analytical Chemistry》 |2020年第6期|共8页
作者
Chioma Don-Lawson; Daniel Okechukwu Nweneka; Reminus Okah; Kingsley J. Orie;
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Furfural11-bis(2-Carbamoylguanidino)furan-2-ylmethaneBioactivity;

机译：Furfural11-BIS（2-碳酰莫薄胍）Furan-2-YlmethaneBioactivity;

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1. Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane [J] . Chioma Don-Lawson, Daniel Okechukwu Nweneka, Reminus Okah, Advances in Biological Chemistry . 2020,第6期

机译：1,1-双（2-氨基甲酰基胍亚胺）呋喃-2-基甲烷的合成，表征和生物活性
2. Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane [J] . Chioma Don-Lawson, Daniel Okechukwu Nweneka, Reminus Okah, 美国分析化学（英文） . 2020,第006期

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Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

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