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首页> 外文期刊>Archives of Animal Breeding >Genetic diversity and genetic origin of Lanping black-boned sheep investigated by genome-wide single-nucleotide polymorphisms (SNPs)
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Genetic diversity and genetic origin of Lanping black-boned sheep investigated by genome-wide single-nucleotide polymorphisms (SNPs)

机译：基因组单核苷酸多态性（SNPS）研究了甘平黑骨羊的遗传多样性和遗传来源

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&p&Lanping black-boned sheep was first discovered in the 1950s in Lanping county of China and characterized by black pigmentation on skin and internal organs. Due to the novel and unique trait, the genetic background of Lanping black-boned sheep is of great interest. Here, we genotyped genome-wide SNPs (single nucleotide polymorphisms) of Lanping black-boned sheep and Lanping normal sheep using Illumina OvineSNP50 BeadChip to investigate the genetic diversity and genetic origin of Lanping black-boned sheep. We also downloaded a subset SNP dataset of two Tibet-lineage sheep breeds and four other sheep breeds from the International Sheep Genomics Consortium?(ISGC) as a reference for interpreting. Lanping black-boned sheep had a lower genetic diversity level when compared to seven other sheep breeds. Principal component analysis?(PCA) showed that Lanping black-boned sheep and Lanping normal sheep were clustered into the Asian group, but there was no clear separation between the two breeds. Structure analysis demonstrated a high ancestry coefficient in Lanping black-boned sheep and Lanping normal sheep. However, the two populations were separated into two distinct branches in a neighbor-joining (NJ) tree. We further evaluated the genetic divergence using population &span class="inline-formula"&&i&F&/i&&sub&ST&/sub&&/span&, which showed that the genetic differentiation that existed between Lanping black-boned sheep and Lanping normal sheep was higher than that between Tibet sheep and Changthangi sheep, which revealed that Lanping black-boned sheep is a different breed from Lanping normal sheep on the genetic level. In addition, structure analysis and NJ tree showed that Lanping black-boned sheep had a relatively close relation with Tibet sheep. The results reported herein are a first step toward understanding the genetic background of Lanping black-boned sheep, and it will provide informative knowledge on the unique genetic resource conservation and mechanism of novel breed formation.&/p&
机译：＆ p＆兰平黑纹羊在20世纪50年代在中国兰平县发现，并在皮肤和内脏的黑色色素沉着。由于新颖而独特的特质，兰坪黑骨羊的遗传背景非常兴趣。在这里，我们使用Illumina ovinesnp50珠芯片的甘杨黑骨绵羊和兰平正常绵的基因组宽的SNPS（单核苷酸多态性），探讨甘坪黑骨羊的遗传多样性和遗传来源。我们还下载了来自国际羊基因组学联盟的两只西藏沿线羊群和四个其他绵羊品种的子集SNP数据集？（ISGC）作为解释的参考。与七种其他绵羊品种相比，兰平黑骨绵羊的遗传多样性较低。主要成分分析？（PCA）显示兰平黑骨绵羊和甘山正常绵羊被聚集到亚洲组中，但两种品种之间没有明确的分离。结构分析表明了兰坪黑骨绵羊和兰平普通羊的高血管系数。然而，将这两种群体分成两个不同的分支，在邻接（NJ）树中。我们进一步使用群体评估了遗传分歧的群体。兰坪黑骨绵羊和兰平正常绵羊的存在于西藏绵羊和常龄绵羊之间存在，这揭示了兰平黑骨绵羊是一种不同品种，局部绵羊在遗传水平上。此外，结构分析和NJ树表明，兰平黑骨绵羊与西藏羊具有相对密切的关系。本文报告的结果是了解兰坪黑骨羊的遗传背景的第一步，它将提供关于新型品种形成的独特遗传资源养护和机制的信息。＆ / p＆

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