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首页> 外文期刊>Annals of Indian Academy of Neurology >Levosulpiride-Induced Neurological Adverse Effects: A Prospective Study from a Tertiary Care Center
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Levosulpiride-Induced Neurological Adverse Effects: A Prospective Study from a Tertiary Care Center

机译：Levosulpiride诱导的神经系统不利影响：第三节护理中心的前瞻性研究

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Background: Levosulpiride (LS) is a prokinetic drug increasingly used for the gastric motility disorders. Despite its common use for the gastric motility disorder, the tendency to cause parkinsonism and acute dystonias are under-recognized as the major adverse effects. This study was aimed to evaluate the adverse effects of this drug in patients attending neurology clinics. Methods: Patients presenting with new-onset extrapyramidal symptoms with respect to LS therapy were selected for the study. A detailed history had been taken using a questionnaire. All the patients were tested for neurological manifestations. The number of cases was then statistically analyzed. Results: A total of 30 patients were diagnosed with LS-induced movement disorders. The average age of patients was 65 ± 12 years with 17 males and remaining females. Major presentations were tremor, stiffness, dystonia, neck or back pain, dysarthria, and abnormal feelings. Stiffness, tremor, or both were among the most common signs. A statistically significant ( P = 0.0154) positive correlation ( r = 0.8295) was found between the duration of LS treatment and incidence of tremor/stiffness. Among them, 19 patients were started with dopaminergic drugs and five were given symptomatic measures. Six patients had no follow-up. Conclusion: The LS treatment was found to produce adverse effects such as tremor and stiffness. Early recognition of this condition is essential for its complete cure and better prognosis. Therefore, one should be cautious about the LS as one of the etiologies for acute recent-onset extrapyramidal syndromes while working up patients.
机译：背景：Levosulpiride（LS）是一种越来越多地用于胃动力障碍的动力药物。尽管胃动力障碍常用，但促使帕金森病和急性Dystonias的趋势被认为是主要的不良反应。本研究旨在评估该药物在参加神经病学诊所的患者中的不利影响。方法：选择患有关于LS疗法的新发作突出瘤症状的患者进行研究。使用调查问卷采取了详细的历史。所有患者均得到神经表现的。然后在统计上分析病例数。结果：共有30名患者被诊断出LS诱导的运动障碍。患者的平均年龄为65±12年，17名男性和剩余的女性。主要演示文稿是震颤，僵硬，缺损，颈部或背部疼痛，缺陷和异常感受。僵硬，震颤或两者都是最常见的迹象。在LS处理的持续时间和震颤/刚度的发生率之间发现了统计学上显着的（p = 0.0154）正相关（R = 0.8295）。其中，19名患者开始于多巴胺能药物，5名患有症状措施。六名患者没有随访。结论：发现LS治疗产生不良反应，如震颤和刚度。早期识别这种情况对于其完全治愈和更好的预后至关重要。因此，一个人应该对LS作为急性近期发作的外显曲线综合征的病因之一，同时致力于患者。

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