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首页> 外文期刊>Arquivo Brasileiro de Medicina Veterinaria e Zootecnia >Leishmaniose cutanea em Cavia porcellus (cobaia): relato de caso
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Leishmaniose cutanea em Cavia porcellus (cobaia): relato de caso

机译：Leishmaniaisis Cutanea在豚鼠Porcellus（Guinau）：案例报告

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摘要

Leishmaniasis is a parasitic disease of worldwide spread. It is caused by protozoa of the genus Leishmania and is transmitted to animals and humans through the bite of sand flies. In Brazil, leishmaniasis is one of the zoonoses of major importance and expansion. The objective of this work is to describe the clinical, pathological, immunohistochemical and molecular findings of cutaneous leishmaniasis by Leishmania enriettii in guinea pig (Cavia porcellus). Three animals had nodular and alopecia lesions on the muzzle, ears and ulcerated lesions on the distal extremities of the pelvic limbs. The males (2) also had diffuse thickening of the scrotal skin. Samples of the ulcerated cutaneous lesions were evaluated by cytology which were observed as amastigote forms of Leishmania. One of the animals was euthanized and necropsied. Histopathology showed abundant dermal infiltrate of macrophages, plasma cells, lymphocytes and multinucleated giant cells. Numerous macrophages contained parasitoid vacuoles with amastigote forms, evidenced by immunohistochemical examination. The molecular characterization based on the SSUrDNA gene identified the species as L. enrietti. The diagnosis of cutaneous leishmaniasis in these cases was based on pathological findings and confirmed by immunohistochemistry, PCR and sequencing.
机译：Leishmaniaisis是全球蔓延的寄生虫病。它是由Leishmania属的原生动物引起的，并且通过咬合苍蝇传递给动物和人类。在巴西，利什曼病是一种主要重要性和扩张的一系列。这项工作的目的是描述豚鼠（Cavia Porcellus）的Leishmania entiattii的皮肤Leishmaniaisis的临床，病理，免疫组化和分子结果。三只动物在腹泻的尿齿上，耳朵和溃疡病变上有结节性和脱发病变。男性（2）还具有阴囊皮肤的弥漫性增厚。通过细胞学评估溃疡性皮肤病变的样品，这些细胞学被观察为Leishmania的Amastigotoote形式。其中一只动物被安乐死和尸检。组织病理学表现出丰富的巨噬细胞，血浆细胞，淋巴细胞和多核巨细胞的真皮渗透。许多巨噬细胞含有寄生虫液泡，具有疟疾形式，通过免疫组化检查证明。基于SSurdNA基因的分子表征鉴定了L.Ventieti的物种。在这些病例中的皮肤利什曼病的诊断基于病理发现，并通过免疫组织化学，PCR和测序证实。

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