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首页> 外文期刊>Annals of Saudi medicine. >Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?
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Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?

机译：在沙特阿拉伯男性学童中的肥胖和儿童哮喘：瘦素，白细胞介素-4，白细胞介素-5和白细胞介素-21有什么作用吗？

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Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma. Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma. Cross-sectional, analytical. Population of schoolchildren in a small Saudi city. The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups. Serum levels of leptin, IL-4, IL-5, and IL-21. 345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years. Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics ( P.001). Uncontrolled asthmatics also had significantly higher leptin levels than controlled asthmatic children ( P.002). Leptin levels were weakly but significantly correlated with the cytokines IL-4, IL-5, and IL-21. Leptin may contribute to a link between obesity and childhood asthma. Differences in IL-21 levels between nonobese and obese asthmatics suggest that the co-existence of asthma and obesity increased IL-21 levels. Leptin plus some proinflammatory cytokines especially IL-21 may be potential predictors for asthma control in children. Blood sampling at different stages of asthma might influence cytokine expression. None.
机译：肥胖与高血清水平的脂肪因子和趋化因子相关，这可能涉及肥胖症和哮喘的共存。阐明瘦素，白细胞介素（IL）-4，IL-5和IL-21将肥胖与儿童哮喘联系起来的可能作用。横截面，分析。小沙特市的学童人口。该研究包括沙特学童代表性样本，被赋予肥胖哮喘，非肥胖哮喘或肥胖的非原始学，非同源的非原始学作为对照组。对哮喘基团进行哮喘控制试验。瘦素，IL-4，IL-5和IL-21的血清水平。 345男性学龄儿童，平均（SD）年龄为13.0（2.3）年。肥胖哮喘患者中位血清瘦素浓度明显高于非同源哮喘（P <.001）。不受控制的哮喘患者含有比对哮喘的哮喘儿童显着更高的瘦素水平（P <.002）。瘦素水平弱但与细胞因子IL-4，IL-5和IL-21显着相关。瘦素可能有助于肥胖和儿童哮喘之间的联系。非同比和肥胖哮喘患者的IL-21水平的差异表明，哮喘和肥胖的共存增加了IL-21水平。 Leptin加上一些促炎细胞因子尤其是IL-21可能是儿童哮喘控制的潜在预测因子。在不同阶段的哮喘血液取样可能影响细胞因子表达。没有任何。

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