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首页> 外文期刊>Indian journal of dermatology >Efficacy of terbinafine and itraconazole in different doses and in combination in the treatment of tinea infection: A randomized controlled parallel group open labeled trial with clinico-mycological correlation
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Efficacy of terbinafine and itraconazole in different doses and in combination in the treatment of tinea infection: A randomized controlled parallel group open labeled trial with clinico-mycological correlation

机译：三苯胺和伊唑康唑在不同剂量中的疗效以及组合在治疗Tinea感染中：随机控制平行组开放标记试验与临床 - Mycology相关性

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Background: There is a rising prevalence of dermatophyte infection especially in the tropics. It has been observed that the antifungals are not as effective as they used to be. Aims: To determine the effectiveness of terbinafine and itraconazole in different doses and in combination in the treatment of tinea infection. Materials and Methods: Study design was a randomized parallel group trial. Patients were randomly divided into five parallel arms in which two of the standard drugs in recommended doses were compared with their double doses and with combination of both the drugs. Patients were followed up every 2 weeks. Outcomes were assessed at 4 and 8 weeks. Cure was considered as complete clinical resolution of the lesions. Fungal culture and sensitivity were done by disk diffusion method for all patients. Parametric one-way analysis of variance (F test) and Chi-square test were used for the analysis. Results: Two-hundred seventy-five patients were included in the study. Itraconazole containing groups showed significantly higher cure rates than terbinafine only groups both at 4 and 8 weeks (P 0.001). Itraconazole containing groups, when compared against each other, were not found to be significantly different. The outcomes between terbinafine only groups were also not significantly different. Cure rates at 8 weeks were found to be greater than that at 4 weeks for all groups which were found to be highly significant (P 0.001). Conclusions: Itraconazole seems to be more effective than terbinafine. There is no benefit in increasing the dose or using a combination regimen in the treatment of tinea. Prolonged duration of treatment is required for complete cure.
机译：背景：尤其是在热带地区的皮肤病感染的普遍存在。已经观察到，抗真菌不如曾经是有效的。目的：确定三苯胺和伊曲康唑种不同剂量的有效性，以及组合治疗Tinea感染。材料和方法：研究设计是一个随机的并联组试验。患者随机分为五个平行臂，其中将两个标准药物中的两种标准药物与其双剂量进行比较，以及两种药物的组合。患者随访每2周一次。结果在4和8周评估。治疗被认为是病变的完整临床分辨率。通过磁盘扩散方法对所有患者进行真菌培养和敏感性。参数单向分析差异（F试验）和Chi-Square测试用于分析。结果：研究中包括两百七十五名患者。含伊丙酮的组在4和8周内仅显示比特布萘胺显着更高的固化率（P <0.001）。含伊丙酮唑群，彼此相比，未发现显着不同。三萘芬的成果也没有显着差异。发现8周的治愈率大于4周的所有群体的速率大于4周，这些群体被发现非常显着（P <0.001）。结论：伊丙康唑似乎比Terbinafine更有效。增加剂量或使用组合方案在治疗癣中没有任何益处。完全治疗需要长时间的治疗时间。

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