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首页> 外文期刊>Indian Dermatology Online Journal >A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata
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A comparative study of therapeutic response to intralesional injections of platelet-rich plasma versus triamcinolone acetonide in alopecia areata

机译：对血小板血小板血浆血浆血浆血浆血浆血糖血糖乙醛乙烯酮血管藻酸碱的比较研究

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Background: Alopecia areata (AA) is a chronic nonscarring alopecia that involves hair follicles and is characterized by patchy areas of hair loss without any signs of clinical inflammation. Platelet-ri-ch plasma (PRP) has a high platelet concentration. Anti-inflammatory effect of PRP may be of great help in AA. Aims and Objectives: Study was conducted to compare the outcome of treatment and side effects of intralesional PRP versus triamcinolone in AA. Materials and Methods: 40 patients with alopecia areata were allocated into 2 groups and treated with triamcinolone and PRP injections. The response was analyzed by SALT score (severity of alopecia tool score) and hair regrowth grade (HRG) scale. Inferential statistical tools such as t-test, Mann–Whitney U test, and Chi-square test were used. Results: 16 patients in each group completed the study. While comparing the decrease in SALT score at different intervals of time, there was a significant difference in SALT score reduction during the second review between PRP group and triamcinolone group (P = 0.028). After the first and final review, results did not show any statistically significant difference between the two groups. While comparing the hair regrowth scale between treatments, there was no statistical significance. 12.5% patients in PRP group reported excellent response after final review (HRG scale 4), compared to none in triamcinolone group. Conclusions: Platelet-rich plasma is a safe, effective, steroid sparing, and suitable alternative in AA. Only side effect noted was pain during injections in both the groups.
机译：背景：Alopecia Areata（AA）是一种慢性非卡曲线的慢性疾病，涉及毛囊，其特征在于脱发的斑块斑块，没有任何临床炎症的迹象。血小板-RI-CH等离子体（PRP）具有高血小板浓度。 PRP的抗炎作用可能在AA中有很大的帮助。目的和目标：进行研究以比较intlalesional prp与riamcinolone在aa中的治疗和副作用的结果。材料和方法：将40例脱钙症患者分配成2组，并用Triamcinolone和PrP注射治疗。通过盐分（Salopecia刀具评分的严重程度）分析响应和毛发再生级（HRG）规模。使用诸如T检验，Mann-Whitney U测试和Chi-Square测试等推理统计工具。结果：每组16名患者完成了这项研究。在比较不同时间间隔的盐分的减少时，PRP组和葡萄氨酸基团之间的第二次审查期间盐成分减少差异有显着差异（P = 0.028）。在第一个和最终审查后，结果没有显示两组之间的任何统计学上差异。在比较治疗之间的头发再生尺度的同时，没有统计学意义。 12.5％的PRP组患者报告在最终审查（HRG SCALE 4）后报告了出色的反应，而无颗粒醇组无关。结论：富含血小板的血浆是一种安全，有效，类固醇的备用，以及AA的合适替代品。只有副作用注意到两组注射期间的疼痛。

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