...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Indian Journal of Medical and Paediatric Oncology >Management and long-term outcomes of giant mediastinal germ cell tumors in children
【24h】

Management and long-term outcomes of giant mediastinal germ cell tumors in children

机译：儿童巨型常剧胚细胞肿瘤的管理和长期结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: The purpose of the study is to evaluate the outcome of children with giant mediastinal germ cell tumors (GCTs). Materials and Methods: A retrospective study of children diagnosed with GCTs treated at our hospital from 1998 to 2014 was performed. They were evaluated for their tumor size, malignancy, treatment, complications, and outcome. Results: Twelve giant mediastinal GCT patients were included in the study. Age ranged from 7 to 144 months (median 12 months) and all except one were males. The average tumor size was 10.4 cm (range 6 cm × 5 cm–16 cm × 13 cm) and in four patients, they were large enough to occupy nearly the entire hemithorax. Nine children had benign tumors, and these were resected upfront. The remaining three cases with malignant disease received neoadjuvant chemotherapy. No significant reduction in size was noticed in these patients, but alpha-fetoprotein levels decreased in all the three, and they were later resected. Eight (67%) were resected through posterolateral thoracotomy and 4 (33%) through median sternotomy approach. One patient had a dumbbell-shaped thoracoabdominal tumor extending through a Bochdalek hernia. He required additional laparotomy as well as diaphragmatic repair. There were no postoperative complications. The malignant GCTs received total four courses of PEB. All patients were alive and asymptomatic at a mean follow-up of 55.4 months (range 10–146 months). Conclusions: Mediastinal GCTs have bimodal age distribution and show male preponderance. Malignant mediastinal GCTs responded well to neoadjuvant chemotherapy through a reduction in size was not noticed. Complete excision often in coordination with cardiothoracic-vascular surgeons can lead to long-term symptom-free survival even in giant tumors.
机译：目的：该研究的目的是评估患有巨型纵隔胚芽细胞肿瘤（GCTS）的儿童的结果。材料与方法：从1998年至2014年申请诊断患有GCT的儿童的回顾性研究。他们评估了它们的肿瘤大小，恶性肿瘤，治疗，并发症和结果。结果：12例巨型纵隔GCT患者被纳入研究。年龄从7到144个月（中位数12个月），除了一个是男性之外。平均肿瘤大小为10.4厘米（范围6cm×5cm-16cm×13厘米），在四个患者中，它们足够大，以占据几乎整个半血缘。九个孩子有良性肿瘤，这些孩子预先切除。剩下的三种患者未恶性疾病接受Neoadjuvant化疗。在这些患者中没有发现大小明显减少，但所有这三个患者中的α-胎蛋白水平降低，后来它们后来被切除。通过后侧胸廓切开术和4（33％）通过中位数术治疗来切除八次（67％）。一名患者有一个哑铃形的胸腔肿瘤，延伸穿过Bochdalek Hernia。他需要额外的剖腹手术和膈肌修复。没有术后并发症。恶性GCTS收到总共四门训练。所有患者均为活力和无症状，平均随访55.4个月（10-146个月）。结论：纵隔GCTS具有双峰年龄分布并显示男性优势。恶性肿瘤GCTS通过未被注意到的尺寸减小对Neoadjuvant化疗进行了良好。通常与心肌血管外科医生协调的完全切除可以导致即使在巨大肿瘤中也能导致长期的无症状生存率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号