Proteomics of Neoplastic Stem Cells in Children's Germ Cell Tumors

机译：儿童胚芽细胞肿瘤肿瘤干细胞蛋白质组学

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Germ cell tumors (GCTs), believed to arise from transformed primordial germ cells by an unknown mechanism, provide evidence that cancers may begin from genetic mutations and epigenetic modifications of single neoplastic stem cells. GCTs comprise approximately 3percent of all malignant childhood tumors and up to 60percent of all malignancies in men between 20 and 40 years of age. Akin to the pluripotency of embryonic stem and germ cells, GCTs contain self-renewing and differentiating stem cells and may result in a variety of neoplastic structures resembling embryonic (endoderm, mesoderm, and ectoderm) and extra-embryonic (yolk sac, trophoblast) derivatives. Indeed, prior to the availability of true embryonic stem cells (ESCs), GCT cell lines were used as surrogates for research on ESCs.

机译：据信通过未知机制由转化的原始生殖细胞产生的生殖细胞肿瘤（GCT）提供了癌症可以从遗传突变和单一肿瘤干细胞的表观遗传修饰开始的证据。 GCTS含有大约3患有所有恶性儿童肿瘤，高达20至40岁的男性所有恶性肿瘤的60％。类似于胚胎茎和生殖细胞的多能性，GCTS含有自我更新和分化干细胞，并且可能导致类似胚胎（内胚层，中胚层和外胚层）和胚胎（卵黄囊，滋养板）衍生物的各种肿瘤结构。实际上，在真正的胚胎干细胞（ESC）的可用性之前，GCT细胞系被用作对ESC的研究的替代品。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2008年||共1页
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SRUTHI EEDALA; Elizabeth Perlman; William E. Haskins;
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1. Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors [J] . HaskinsW.E., EedalaS., AvinashJadhavY.L., Pediatric blood & cancer . 2012,第5期

机译：从童年期生殖细胞肿瘤的凝胶蛋白质组学中了解肿瘤干细胞
2. A Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT): A Children's Oncology Group (COG) Study. Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors [J] . Murphy E. S., Fangusaro J., Dhall G., International Journal of Radiation Oncology, Biology, Physics . 2018,第3Suppla期

机译：局部中枢神经系统生殖细胞肿瘤患者（CNS GCT）的响应基于响应的放射治疗的2阶段试验：儿童肿瘤组（COG）研究。不胺胚芽细胞肿瘤的失效与辐射剂量测量法
3. Application of the adult international germ cell classification system to pediatric malignant non-seminomatous germ cell tumors: a report from the Children's Oncology Group. [J] . Frazier AL, Rumcheva P, Olson T, Pediatric blood & cancer . 2008,第4期

机译：成人国际生殖细胞分类系统在儿童恶性非精原细胞生殖细胞肿瘤中的应用：儿童肿瘤学组的报告。
4. Proteomics of Neoplastic Stem Cells in Children's Germ Cell Tumors [C] . SRUTHI EEDALA, Elizabeth Perlman, William E. Haskins ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：儿童胚芽细胞肿瘤肿瘤干细胞蛋白质组学
5. Over-expression of cell cycle kinases, cyclin D-Cdk4, cyclin E-Cdk2, and Aurora A kinase in estrogen-induced pre-neoplastic mammary lesions and tumors in the female ACI rat. [D] . Weroha, Saravut John. 2006

机译：细胞周期激酶，细胞周期蛋白D-Cdk4，细胞周期蛋白E-Cdk2和Aurora A激酶在雌激素诱发的雌性ACI大鼠的乳腺肿瘤前肿瘤病变和肿瘤中的过度表达。
6. Insights on Neoplastic Stem Cells from Gel-Based Proteomics of Childhood Germ Cell Tumors [O] . William E. Haskins, Sruthi Eedala, Y.L. Avinash Jadhav, -1

机译：儿童生殖细胞肿瘤凝胶蛋白质组学对肿瘤干细胞的见解
7. Primary mediastinal germ cell tumor with intratubular germ cell neoplasia of the testis--further support for germ cell origin of these tumors [O] . Seife Hailemariam, Daniel S. Engeler, Fridolin Bannwart, 1997

机译：原发性纵隔胚芽细胞肿瘤与睾丸瘤胚芽细胞瘤形成 - 进一步支持这些肿瘤的生殖细胞源性

Proteomics of Neoplastic Stem Cells in Children's Germ Cell Tumors

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