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首页> 外文期刊>Indian Journal of Medical and Paediatric Oncology >Tumor-infiltrating lymphocytes in Wilms tumor
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Tumor-infiltrating lymphocytes in Wilms tumor

机译：Wilms肿瘤中的肿瘤浸润淋巴细胞

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Purpose: T-lymphocytes-infiltrating tumors (TILs) are white blood cells (CD3+) found within the tumor and are thought to indicate a T-cell-mediated specific immune response. The purpose was to evaluate the presence and the subtypes of TILs in Wilms tumor (WT) specimens. Materials and Methods: A prospective study was conducted, and consecutive cases of WT registered and treated at our center were included in the study. The resected tumor was processed by taking multiple sections from the tumor and the peritumoral area. The sections were then processed for evaluating TILs and their subtypes (CD4 + and CD8+). TILs were assessed as a percentage of the total mononuclear cell infiltration in both these areas in all specimens. Results: Twenty-four consecutive specimens of WT were studied. The mean TILs (CD3+) counts was significantly higher (P = 0.001) in the peritumoral area (22.64 ± 1.42; range 20.2%–25%) as compared to the tumor (21.08 ± 2.42; range 14.6%–23.1%). The mean T-Helper (CD4+) counts was also significantly higher (P 0.001) in the peritumoral area (13.04 ± 1.79; range 10.5%–16.5%) than in the tumor (7.30 ± 1.81; range 4.2%–10.1%). The mean cytolytic T-lymphocytes (CTLs-CD8+) counts in peritumoral area were 6.64 ± 1.09 (range 4.2%–9.2%), while in the tumor, it was 11.96 ± 3.09 (range 3.6%–16.4%). Two patients died on follow-up due to recurrence. These patients showed a markedly lower CD8+ cell count and higher CD4+/CD8+ ratio in the tumor. Conclusion: T-cells infiltration takes place in WT, and most of the patients demonstrate a higher concentration of CTL (CD8+) in the tumor as compared to the peritumoral area.
机译：目的：T淋巴细胞浸润肿瘤（TIL）是肿瘤内发现的白细胞（CD3 +），并被认为表示T细胞介导的特异性免疫应答。目的是评估Wilms肿瘤（WT）标本中TILS的存在和亚型。材料和方法：进行了前瞻性研究，并在我们中心注册和治疗的连续病例包括在研究中。通过从肿瘤和Peritumoral区域取出多个部分加工切除的肿瘤。然后将该部分加工用于评估TILS及其亚型（CD4 +和CD8 +）。在所有标本中的两个区域中，将TIL被评估为单核细胞浸润总量的百分比。结果：研究了二十四个连续的WT标本。与肿瘤相比，平均直线（CD3 +）计数显着高（P = 0.001）（22.64±1.42;范围20.2％-25％）（21.08±2.42;范围14.6％-23.1％）。 Peritumoral区域的平均T-助杆（CD4 +）计数也显着高（p <0.001）（13.04±1.79;范围为10.5％-16.5％）（7.30±1.81;范围4.2％-10.1％） 。腹部区域的平均细胞溶解淋巴细胞（CTLS-CD8 +）计数为6.64±1.09（范围4.2％-9.2％），而在肿瘤中，为11.96±3.09（范围3.6％-16.4％）。两名患者因再次发生而导致随访。这些患者在肿瘤中显示出明显降低的CD8 +细胞计数和更高的CD4 + / CD8 +比。结论：T细胞渗透发生在WT中，大多数患者与肿瘤区域相比，肿瘤中的浓度较高浓度的CTL（CD8 +）。

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