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首页> 外文期刊>Internal medicine. >Diagnostic Value of the Serum Galactomannan and (1, 3)-β-D-glucan Assays for Invasive Pulmonary Aspergillosis in Non-neutropenic Patients
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Diagnostic Value of the Serum Galactomannan and (1, 3)-β-D-glucan Assays for Invasive Pulmonary Aspergillosis in Non-neutropenic Patients

机译：血清半乳甘露聚糖的诊断值和（1,3）-β-D-葡聚糖测定的非中性患者侵袭性肺动脉杆菌病

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Objective Galactomannan (GM) and (1, 3)-β-D-glucan (BG) are considered useful seromarkers for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with neutropenia. However, there is still limited data on these seromarkers for testing non-neutropenic patients who are at the risk of IPA. The aim of this study was to evaluate the value of these two serum antigen assays for the early diagnosis of IPA in patients without neutropenia. Methods Between January 2011 and December 2012, 97 patients with suspected IPA admitted to the department of respiratory diseases and the respiratory intensive care unit were prospectively monitored. Serum GM and BG assays were performed before the patients received antifungal therapy. Results Patients were classified as proven IPA (n=11), probable IPA (n=16), possible IPA (n=4), or non-IPA (n=66). The most common underlying disease of patients with IPA was chronic obstructive pulmonary disease (18.5%), and 22.2% patients with IPA had no known diseases. The sensitivities, specificities, and positive and negative predictive values of the GM and BG assays and at least one positive on both assays were 40.7%/89.4%/61.1%/78.7%, 48.1%/78.8%/48.1%/78.8%, and 70.4%/75.8%/54.3%/86.2%, respectively. Conclusion Compared with the testing of neutropenic patients, the serum GM or BG assay alone was less useful for the diagnosis of IPA in non-neutropenic patients. However, at least one positive result of the two serum assays appeared to be useful in the diagnosis of IPA in non-neutropenic patients.
机译：目标半乳甘露乳甘油（GM）和（1,3）-β-D-葡聚糖（BG）被认为是有用的血清标志物，用于诊断中性粒细胞病患者的侵袭性肺动脉杆菌（IPA）。然而，这些血清网上仍有有限的数据，用于测试患有IPA风险的非中性患者。本研究的目的是评估这两种血清抗原测定的价值，以便在没有中性病症的患者中的IPA早期诊断。方法2011年1月至2012年12月，97名涉嫌IPA患者入院，呼吸疾病和呼吸系统重症监护部门进行了监测。在患者接受抗真菌疗法之前进行血清GM和BG测定。结果患者被归类为经过验证的IPA（n = 11），可能的IPA（n = 16），可能的IPA（n = 4）或非IPA（n = 66）。 IPA患者的最常见的潜在疾病是慢性阻塞性肺病（18.5％），22.2％的IPA患者没有已知的疾病。 GM和BG测定的敏感性，特异性和正面和阴性预测值和至少一个测定的阳性为40.7％/ 89.4％/ 61.1％/ 78.7％，48.1％/ 78.8％/ 48.1％/ 78.8％， 70.4％/ 75.8％/ 54.3％/ 86.2％。结论与中性患者的测试相比，单独血清GM或BG测定对非中性患者IPA的诊断不太有用。然而，两个血清测定的至少一个阳性结果似乎可用于非中性患者IPA的诊断。

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