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首页> 外文期刊>International braz j urol >Can neutrophil to lymphocyte ratio predict lamina propria invasion in patients with non muscle invasive bladder cancer?
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Can neutrophil to lymphocyte ratio predict lamina propria invasion in patients with non muscle invasive bladder cancer?

机译：可以使淋巴细胞比率预​​测患有非肌肉侵袭性膀胱癌的椎相子血栓侵袭吗？

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Objective Recent studies have demonstrated the role of systemic inflammation in the development and progression of cancer. In this study, we evaluated whether preoperatively measured neutrophil-to-lymphocyte ratio (NLR) can predict lamina propria invasion in patients with non-muscle-invasive bladder cancer (NMIBC). Material and Methods We reviewed the medical records of 304 consecutive and newly diagnosed patients with bladder cancer who had been treated with transurethral resection between January 2008 and June 2014. In total, 271 patients were included in the study and the patients were divided into two groups according to the pathological stage (Group 1: Ta, Group 2: T1). NLR was calculated by dividing the absolute neutrophil count (N) by the absolute lymphocyte count (L). Results In total, 271 patients (27 women and 244 men) were enrolled. Mean age was higher in Group 2 than in Group 1 (67.3±10.8 vs. 62.9±10.8, p<0.001). Furthermore, the presence of high grade tumors and tumors ≥3cm in size was statistically higher in Group 2 than in Group 1 (70.9% vs. 9.9%, p=0.0001; 71.8% vs. 36%, p=0.0001, respectively). While the mean white blood cell (WBC) and N counts were statistically insignificant (7.63±1.87 vs. 7.69±1.93, p=0.780; 4.72±1.54 vs. 4.46±1.38, p=0.140; respectively), L was significantly lower and NLR was significantly higher in Group 2 than in Group 1 (2.07±0.75 vs. 2.4±0.87, p=0.001; 2.62±1.5 vs. 2.19±1.62, p=0.029; respectively). Conclusion Our data indicate that high NLR and low L are statistically associated with T1 stage, whereas low L are able to predict lamina propria invasion in patients with NMIBC. These findings suggest that pretreatment measurement of NLR may provide valuable information for the clinical management of patients with NMIBC. Prospective studies are now required to further validate the role of NLR as a risk factor in NMIBC.
机译：目的近来的研究表明了全身炎症在癌症的开发和进展中的作用。在该研究中，我们评估了术前测量的中性粒细胞对淋巴细胞比（NLR）可以预测非肌肉侵入性膀胱癌（NMIBC）患者的椎板丙醇侵袭。材料和方法我们审查了304次连续和新诊断的膀胱癌患者的病历记录，该膀胱癌患者于2008年1月至2014年6月至6月在2014年6月之间进行治疗。总共包括271名患者，患者分为两组根据病理阶段（第1组：TA，第2组：T1）。通过将绝对淋巴细胞计数（L）除以绝对淋巴细胞计数（N）来计算NLR。共有271名患者（27名妇女和244名男性）。第2组的平均年龄高于1（67.3±10.8 vs.6.9±10.8，P <0.001）。此外，高级肿瘤和肿瘤的存在≥3厘米的尺寸比第1组统计学上较高（70.9％与9.9％，p = 0.0001; 71.8％，分别为71.8％，P = 0.0001）。而平均白细胞（WBC）和N计数均无统计学上（7.63±1.87，7.69±1.93，P = 0.780; 4.72±1.54与4.46±1.38，P = 0.140），L显着降低和第2组的NLR显着高于1组（2.07±0.75 Vs.2.4±0.87，P = 0.001; 2.62±1.5与2.19±1.62，P = 0.029）。结论我们的数据表明，高NLR和低L与T1阶段有统计学相关，而低L能够预测NMIBC患者的Lamina Propria侵袭。这些发现表明，NLR的预处理测量可以为NMIBC患者的临床管理提供有价值的信息。现在需要预期研究，以进一步验证NLR作为NMIBC危险因素的作用。

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