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首页> 外文期刊>International Journal of Environmental Research and Public Health >A Simple Model of Tetracycline Antibiotic Resistance in the Aquatic Environment (with Application to the Poudre River)
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A Simple Model of Tetracycline Antibiotic Resistance in the Aquatic Environment (with Application to the Poudre River)

机译：水生环境中四环素抗生素抗性的简单模型（应用于Poudre河）

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Antibiotic resistance is a major concern, yet it is unclear what causes the relatively high densities of resistant bacteria in the anthropogenically impacted environment. There are various possible scenarios (hypotheses): (A) Input of resistant bacteria from wastewater and agricultural sources is significant, but they do not grow in the environment; (B) Input of resistant bacteria is negligible, but the resistant bacteria (exogenous or endogenous) grow due to the selection pressure of the antibiotic; (C) Exogenous bacteria transfer the resistance to the endogenous bacteria and those grow. This paper presents a simple mechanistic model of tetracycline resistance in the aquatic environment. It includes state variables for tetracyclines, susceptible and resistant bacteria, and particulate and dissolved organic matter in the water column and sediment bed. The antibiotic partitions between freely dissolved, dissolved organic matter (DOM)-bound and solids-bound phases, and decays. Bacteria growth is limited by DOM, inhibited by the antibiotic (susceptible bacteria only) and lower due to the metabolic cost of carrying the resistance (resistant bacteria only). Resistant bacteria can transfer resistance to the susceptible bacteria (conjugation) and lose the resistance (segregation). The model is applied to the Poudre River and can reproduce the major observed (literature data) patterns of antibiotic concentration and resistance. The model suggests observed densities of resistant bacteria in the sediment bed cannot be explained by input (scenario A), but require growth (scenarios B or C).
机译：抗生素抗性是一个主要问题，但目前尚不清楚导致人为受影响的环境中抗性细菌相对高的密度。有各种可能的情景（假设）：（a）从废水和农业来源的抗性细菌的输入是显着的，但它们不会在环境中生长; （b）抗性细菌的输入可忽略不计，但由于抗生素的选择压力，抗性细菌（外源或内源）生长; （c）外源细菌转移对内源性细菌的抗性和生长。本文介绍了水生环境中四环素抗性的简单机械模型。它包括用于四环素，易感和抗性细菌的状态变量，以及水柱和沉积床中的颗粒和溶解有机物。自由溶解，溶解的有机物质（DOM） - 基和固相结合的抗生素分区，并腐蚀。由于携带抗性（仅抗性细菌的代谢成本，细菌生长受DOM的限制，受到抗生素（易感细菌）和降低的影响。抗性细菌可以转移对易感细菌（缀合）的抗性并失去抗性（偏析）。该模型应用于Poudre河，可以再现抗生素浓度和抗性的主要观察到的（文献数据）模式。该模型表明观察到沉积物床中的抗性细菌的密度不能通过输入（场景A）来解释，但需要增长（情景B或C）。

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