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首页> 外文期刊>International Journal of Environmental Research and Public Health >Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study
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Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study

机译：患有预先血糖肾病的成人的药物依从性，负担和健康相关的生活质量：一项潜在的队列研究

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This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m 2 ) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m 2 . Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.
机译：本研究探讨了预依旧慢性肾病（CKD）中药物依从性和负担的协会，以及相关的患者生活质量（HRQOL）。靶向CKD（估计肾小球过滤速率（EGFR）<30ml / min / 1.73m 2）的前瞻性研究，在澳大利亚塔斯马尼亚举行，未接受肾置换疗法。使用65项药物治疗方案复杂性指数评估实际的药物负担，而使用简要验证的调查问卷是自我报告的感知负担。使用四项Morisky-Green-Levine Scale（MGL）和粘附行为筛选的工具进行评估药物遵守（标签）。肾脏疾病和生命质量短，用于评估HRQOL。在464个符合条件的成年人中，101人参加了基线采访，63人在14个月内完成后续采访。参与者主要是男性（67％），平均年龄为72（SD 11）岁，EGFR为21（SD 6）ml / min / 1.73m 2。总体而言，43％和60％的参与者分别报告了基于MGLS和标签的药物不正常。更高的感知药物负担和对决策的愿望与非正当行为有关。较贫穷的HRQOL与更高的方案复杂性有关，而非正常与物理HRQOL的下降相关。由感知药物负担驱动的药物不正常在这种队列中普遍存在，并且随着时间的推移与物理HRQOL的下降有关。

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