...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan
【24h】

Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan

机译：幽门螺杆菌感染患者肠易激综合征风险：台湾全国范围的群体研究队列研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The association between Helicobacter pylori ( H. pylori ) infection and the risk of developing irritable bowel syndrome (IBS) has yet to be investigated; thus, we conducted this nationwide cohort study to examine the association in patients from Taiwan. Methods: A total of approximately 2669 individuals with newly diagnosed H. pylori infection and 10,676 age- and sex-matched patients without a diagnosis of H. pylori infection from 2000 to 2013 were identified from Taiwan’s National Health Insurance Research Database. The Kaplan–Meier method was used to determine the cumulative incidence of H. pylori infection in each cohort. Whether the patient underwent H. pylori eradication therapy was also determined. Results: The cumulative incidence of IBS was higher in the H. pylori -infected cohort than in the comparison cohort (log-rank test, p 0.001). After adjustment for potential confounders, H. pylori infection was associated with a significantly increased risk of IBS (adjusted hazard ratio (aHR) 3.108, p 0.001). In addition, the H. pylori -infected cohort who did not receive eradication therapy had a higher risk of IBS than the non- H. pylori -infected cohort (adjusted HR 4.16, p 0.001). The H. pylori -infected cohort who received eradication therapy had a lower risk of IBS than the comparison cohort (adjusted HR 0.464, p = 0.037). Conclusions: Based on a retrospective follow-up, nationwide study in Taiwan, H. pylori infection was associated with an increased risk of IBS; however, aggressive H. pylori infection eradication therapy can also reduce the risk of IBS. Further underlying biological mechanistic research is needed.
机译：背景：幽门螺杆菌（H. Pylori）感染与发育肠易肠综合征（IBS）的风险之间的关联尚未调查;因此，我们在全国范围内进行了群组研究，以检查台湾患者的关联。方法：从台湾全国医疗保险研究数据库确定，共有约2669名具有新诊断的H.幽门螺杆菌感染和10,676名患者，没有诊断到2013年的幽门螺杆菌感染。 Kaplan-Meier方法用于确定每个队列中H.幽门螺杆菌感染的累积发生率。还确定了患者是否接受了幽门螺杆菌根除疗法。结果：H.幽门螺杆菌的累积率高于比较队列（对数级试验，P <0.001）。调整潜在混凝剂后，H.幽门螺杆菌感染与IBS的风险显着增加有关（调整后危险比（AHR）3.108，P <0.001）。此外，未接受根除治疗的H.幽门螺缩植物的群体的IBS风险较高，而不是非幽门螺杆菌的队列（调节的HR 4.16，P <0.001）。接受根除治疗的H. Pylori-inved群组的IBS风险低于比较队列（调整后的HR 0.464，P = 0.037）。结论：基于回顾性随访，全国范围内的台湾研究，H.幽门螺杆菌感染与IBS的风险增加有关;然而，侵袭性H.幽门螺杆菌感染根除治疗也可以降低IBS的风险。需要进一步潜在的生物机制研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号