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首页> 外文期刊>International Journal of Research in Medical Sciences >Detection of malarial parasite in urine of malaria patients: a future diagnostic approach
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Detection of malarial parasite in urine of malaria patients: a future diagnostic approach

机译：疟疾患者尿液中疟原虫的检测：未来的诊断方法

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Background: Current definitive screening for active malaria infection necessitates drawing blood. The non-invasive, cost-effective malaria tests that minimize the need for blood collection are the need of time. QDx Malaria PAN/Pf rapid malaria card test (QDx rapid malaria test) is an immunochromatographic test that detects the presence of malarial antigens (pLDH and HRP-2) in the blood sample for the diagnosis of malaria. These malarial antigens are also released in the urine. The study was conducted to determine the sensitivity, specificity and accuracy of the QDx Rapid Malaria test for diagnosis of malaria in blood and urine. Methods: Blood and urine specimens were obtained from 75 malaria blood smear positive cases (test samples) and 25 malarial negative cases (controls). Then urine and blood specimen of each case were evaluated for QDx rapid malaria test. Using microscopy as gold standard, the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of the QDx rapid malaria test for urine and blood were calculated. Results: The accuracy of QDx rapid malaria test for malarial parasite detection was 97% for blood and 38 % for urine. Conclusions: Rapid malaria test processed with urine may be a useful non-invasive and cost-effective malaria diagnostic technique in future.
机译：背景：目前活跃疟疾感染的当前筛选需要吸血。无侵入性，具有成本效益的疟疾测试，最小化血液收集的需要是时间。 QDX疟疾PAN / PF快速疟疾卡测试（QDX快速疟疾测试）是免疫色谱试验，可检测血液样本中疟疾抗原（PLDH和HRP-2）的存在，用于诊断疟疾。这些疟原虫抗原也释放在尿液中。进行该研究以确定QDX快速疟疾试验的敏感性，特异性和准确性，以诊断血液和尿液中疟疾的诊断。方法：从75名疟疾血液涂片阳性病例（试样）和25例疟原虫阴性病例（对照）获得血液和尿样。然后评估每种情况的尿液和血液标本对QDX快速疟疾测试进行评估。计算使用显微镜作为金标准，计算QDX尿液和血液快速疟疾试验的敏感性，特异性，准确性，阳性预测值（PPV）和负预测值（NPV）。结果：疟原虫检测QDX快速疟疾试验的准确性为血液的97％，尿液38％。结论：用尿液加工的快速疟疾试验可能是未来有用的无侵入性和具有成本效益的疟疾诊断技术。

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