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首页> 外文期刊>International Journal of Research in Medical Sciences >Study of insulin resistance and antioxidant vitamin status in prostate cancer patients
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Study of insulin resistance and antioxidant vitamin status in prostate cancer patients

机译：前列腺癌患者胰岛素抵抗和抗氧化维生素状态研究

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The incidence of prostate cancer is 5 per 100000 in southern and eastern Asia. Both genetic and environmental factors have been implicated in its etiology. The mitogenic and growth stimulatory effects of Insulin growth factor may be involved in prostate carcinogenesis. To evaluate serum insulin and insulin resistance was passed by HOMA- IR. Prostatic specific antigen passed by immune-enzymatic assay. Vitamins were estimated by high performance liquid chromatography. In our study 30 prostate cancer patients aged 60-80years were taken as cases. 30 normal age matched disease free person were taken as controls in both groups, Insulin resistance and antioxidant vitamin status was studied. In the present study, the value of HOMA-IR was (P <0.05) is significantly higher compare to controls. Serum vitamin E and vitamin C values for cases was reduced (P <0.05) significantly lower than controls. The development of prostate cancer is a multistep process. Hyperinsulinemia associated with insulin resistance may play a role in pathogenesis of prostate cancer. Prostate cancer cells generate high levels a ROS.
机译：前列腺癌的发病率为南亚和东亚每10万人5000人。遗传和环境因素都涉及其病因。胰岛素生长因子的丝粉膜炎和生长刺激作用可参与前列腺发生癌。评估血清胰岛素和胰岛素抗性通过HOMA-IR通过。前列腺特异性抗原通过免疫酶测定法通过。通过高效液相色谱估计维生素。在我们的研究中，30名60-80岁的前列腺癌患者被视为病例。 30个正常年龄匹配的疾病自由人作为对照组在两组中，研究了胰岛素抵抗和抗氧化维生素状态。在本研究中，HOMA-IR的值（P <0.05）与对照相比显着更高。病例的血清维生素E和维生素C值（P <0.05）显着低于对照。前列腺癌的发展是一个多步骤过程。与胰岛素抗性相关的高胰岛素血症可能在前列腺癌的发病机制中发挥作用。前列腺癌细胞产生高水平的ROS。

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