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首页> 外文期刊>International Journal of Research in Medical Sciences >A comparative study of inflammatory marker highly sensitive C- Reactive Protein in depression patients exhibiting suicidal behaviour and depression patients without suicidal behaviour
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A comparative study of inflammatory marker highly sensitive C- Reactive Protein in depression patients exhibiting suicidal behaviour and depression patients without suicidal behaviour

机译：抑郁症患者炎症标志物高敏感性C-无反应性蛋白的对比研究，抑郁症患者在没有自杀行为的基因行为和抑郁症患者

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Background: Recent research have found a link between inflammatory pathway and suicidal behaviour. hs-CRP, IL, TNF have been shown to have significant alterations in suicidality, however multiple covariates influence this relationship. One of the main limitations of most of the studies is that they have evaluated the CRP in patients demonstrating suicidal behaviour but not in depression. No study has been conducted in Indian subpopulation with parameters of our study. Aims of the study was to compare hsCRP levels between depression patients with suicidal behaviour and without suicidal behaviour. Methods: Authors compared 50 depression patients with suicidal behaviour and 50 depression patients without suicidal behaviour, diagnosed using ICD10. Hamilton Depression Rating Scale (HDRS?17), Suicide behaviour Questionnaire- Revised (SBQ-R), Beck Scale for Suicidal Ideation (BSSI) were applied for assessment of depression and suicidality. Highly sensitive CRP was measured using autoanalyzer. Results: hsCRP levels were significantly high in depression patients with suicidal behaviour (4.12 mg/dl) than depression without suicidal behaviour (2.42 mg/dl). Duration of illness, HAM-D, BSSI and SBQ-R scores correlated positively with hsCRP levels. Conclusions: Depression with suicidal behaviour patients have a significantly higher hs-CRP levels than depression without suicidal behaviour. Patients of depression with suicidal behaviour group have a strong positive correlation between hs-CRP levels and HAM-D, BSSI and SBQ-R scores.
机译：背景：最近的研究发现炎症途径和自杀行为之间的联系。 HS-CRP，IL，TNF已被证明在自由性方面具有显着的改变，但多个协变量会影响这种关系。大多数研究的主要局限之一是他们已经评估了显示自杀行为但不抑郁症的患者的CRP。在印度亚贫困中没有进行研究，我们的研究参数进行了。该研究的目的是比较抑郁症患者的HSCRP水平，并且没有自杀行为。方法：作者对50例抑郁症患者进行了比较了自杀行为和50名没有自杀行为的抑郁症患者，使用ICD10诊断。汉密尔顿抑郁症评定量表（HDRS？17），自杀行为问卷调查（SBQ-R），用于自杀思想（BSSI）的Beck规模用于评估抑郁和自由性。使用自动分析仪测量高度敏感的CRP。结果：抑郁症患者（4.12mg / d1）的抑郁症患者的抑郁症患者显着高于抑郁症，而不含许可行为（2.42mg / dl）。疾病的持续时间，HAM-D，BSSI和SBQ-R分数与HSCRP水平正相关。结论：自杀行为患者的抑郁症患者的HS-CRP水平明显高于抑郁症，而不会发生自杀行为。抑郁症具有自杀行为组的抑郁症患者在HS-CRP水平和HAM-D，BSSI和SBQ-R分数之间具有强烈的正相关性。

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