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An observational study of clinical profile and outcome of syphilis infection during pregnancy in the tertiary care center

机译:三级护理中心怀孕期间梅毒感染的临床剖面与疗效观察研究

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Background: Syphilis is a sexually transmitted disease (STD) caused by the bacterium treponema pallidum, but little is known about its mechanism of action. In pregnancy it leads to adverse outcomes among more than half of the women with active disease, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death. Methods: It is an observational study in the department of obstetrics and gynecology Mahatma Gandhi Memorial Medical College Maharaja Yashwant Rao Hospital, Indore between January 2014 to December 2015 total 20870. In Include written informed consent, All the patients attending STI/RTI clinic with clinical diagnosis of STD. In Exclusion criteria include patients not give informed consent. Case definition: All VDRL + TPHA positive patients. Results: Out of 20870 females on which VDRL was performed 77 (0.036%) were found to be positive. The seroprevalence at study hospital thus came out to be 0.036%. These were further confirmed by TPHA and 73 (94.8%) out of 77 samples were positive. A total agreement was seen between TPHA and VDRL with a titer of 1 in 8 and above. Among total 20870 screened females, 77% (16101) were ANC patients of which 26 cases out of 77 that is 33.76% females were syphilis positive. Conclusions: Low prevalence of syphilis in pregnant women and adult general population is very encouraging. participation of people and public health approach to promote awareness of syphilis among physicians and populations at risk in India are very urgently needed to avoid the adverse consequences which could result from undiagnosed or improper treatment.
机译:背景:梅毒是由细菌培养的肺炎菌菌菌引起的性传播疾病(STD),但对其作用机制很少。在怀孕期间,它导致超过一半的患有活跃疾病的女性的不利结果,包括早期胎儿丧失,死产,早产,低出生体重,新生儿和婴儿死亡。方法:是2015年1月至2015年1月间2015年1月间的妇女甘肃甘肃纪念医学院Maharaja Yashwant Rao医院的观察研究总数为20870年。在包括书面知情同意书,所有患者与临床一起参加STI / RTI诊所的患者。 STD的诊断。在排除标准中,包括患者未提供知情同意。案例定义:所有VDRL + TPHA阳性患者。结果:在20870年的女性中,vdrl的雌性77(0.036%)被发现是阳性的。学习医院的Seroprevalence因此出现了0.036%。通过TPHA和77个样品中的73(94.8%)进一步证实了这些阳性。在TPHA和VDRL之间看到了总协议,其中滴度为1,8及以上。在20870年筛查的女性中,77%(16101)是ANC患者,其中77例为33.76%的女性是梅毒阳性。结论:孕妇梅毒的低普及率和成人一般人口非常令人鼓舞。人们的参与和公共卫生方法促进印度风险的医生和人口中梅毒的认识,以避免未确诊或不当治疗可能导致的不利后果。

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