• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Nanomedicine >A comparison of poly-ethylene-glycol-coated and uncoated gold nanoparticle-mediated hepatotoxicity and oxidative stress in Sprague Dawley rats
【24h】

A comparison of poly-ethylene-glycol-coated and uncoated gold nanoparticle-mediated hepatotoxicity and oxidative stress in Sprague Dawley rats

机译：聚乙二醇涂层和未涂覆的金纳米粒子介导的肝毒性和氧化胁迫在Sprague Dawley大鼠的比较

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Gold nanoparticles (GNPs) and their functional derivatives are of great interest because of their many biomedical applications. GNPs are increasingly being incorporated into new diagnostic and therapeutic approaches in medicine. Consequently, there has been a strong push to fully understand their interactions with blood components. The agglomeration of cells reflects the interaction of nanoparticles with blood components. Methods: The main aim of this study was to compare the effects of poly-ethylene-glycol (PEG)-oated and uncoated GNPs on the generation of reactive oxygen species (ROS); on the actions of distinct hepatotoxicity biomarkers such as alanine (ALT) and aspartate (AST) aminotransferases, and alkaline phosphatase (ALP); and on the histology of liver tissues in the rat model. Four distinct doses of PEG-coated and uncoated GNPs (12.5, 25, 50, and 100 μg/kg body weight) were used. Each group consisted of three rats receiving an oral administration of PEG-coated and uncoated GNPs for 5 days with one dose per 24?hours. The control group consisted of three rats that received deionized water. Twenty-four hours after the last treatment, samples were collected following standard procedures. Results: PEG-coated and uncoated GNPs enhanced the generation of ROS and the activity of serum aminotransferases (ALT/AST) and ALPs relative to the negative control. A liver histology assessment of GNP-exposed rats revealed statistically significant responses in the variation of the morphologies of tissues relative to those of the negative control. Nonetheless, uncoated GNPs demonstrated enhanced hepatotoxic outcomes relative to those of PEG-coated GNPs. The results demonstrated that both GNPs may be able to promote hepatotoxicity in Sprague Dawley rats through mechanisms of oxidative stress. However, uncoated GNPs have more harmful effects than PEG-coated GNPs relative to the negative control. Conclusion: Taken together, the results of this study indicate that PEG-coated GNPs may be safer to use in nanomedicinal applications than uncoated GNPs. However, more studies must be performed to confirm the outcomes of PEGylation.
机译：背景：由于许多生物医学应用，金纳米颗粒（GNP）及其功能衍生物具有很大的兴趣。 GNP越来越多地被纳入新的医学诊断和治疗方法。因此，有强烈推动充分了解他们与血液成分的相互作用。细胞的凝聚反映了纳米颗粒与血液成分的相互作用。方法：本研究的主要目的是比较聚乙二醇（PEG）〜-Oated和未涂覆的GNP对反应性氧物种（ROS）的影响的影响;关于不同肝毒性生物标志物，如丙氨酸（ALT）和天冬氨酸（AST）氨基转移酶和碱性磷酸酶（ALP）的作用;对大鼠模型中肝组织的组织学。使用四种不同剂量的涂覆的PEG涂覆和未涂覆的GNPS（12.5,25,50和100μg/ kg体重）。每组由三只大鼠组成，接受口服施用PEG涂覆和未涂覆的GNPS 5天，每24小时一次剂量。对照组由三种接受去离子水的大鼠组成。最后一次治疗后二十四小时，按标准程序收集样品。结果：PEG涂层和未涂覆的GNPS增强了ROS的产生和血清氨基转移酶（ALT / AST）和ALP的活性相对于阴性对照。 GNP暴露大鼠的肝脏组织学评估揭示了与阴性对照组织形态的变异的统计学上显着的反应。尽管如此，未涂覆的GNPS相对于PEG涂覆的GNP的那些证明了增强的肝毒性结果。结果表明，通过氧化应激机制，GNP均可促进Sprague Dawley大鼠的肝毒性。然而，未涂覆的GNPS相对于阴性对照具有比PEG涂覆的GNP更有害的效果。结论：结束，该研究的结果表明，在纳米闭土的应用中，PEG涂覆的GNP可能比未涂覆的GNP更安全。然而，必须进行更多的研究以确认pegymation的结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号