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首页> 外文期刊>International Journal of Surgical Oncology >Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection
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Predictive Factors of Positive Circumferential and Longitudinal Margins in Early T3 Colorectal Cancer Resection

机译：早期T3结直肠癌切除率正圆周和纵向边缘的预测因素

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Background. Malignant involvement of circumferential resection margin (CRM) and longitudinal resection margin (LRM) after surgical resection of colorectal cancer (CRC) are associated with higher rates of recurrence and development of distant metastasis. This can influence the overall patient’s prognosis. The aim of the current study was to identify pathological factors as predictors for the involvement of resection margins in early T3 CRC. Patients and Methods. Fifty patients radiologically diagnosed to have cT3a/b (CRC) were included in the study. After resection, the pathological examination was performed to identify patients with positive CRM and/or LRM. Relations between the different pathological parameters and the CMR and LRM involvements were assessed. Results. Positive CRM was present in 17 cases (34%), while positive LRM was found in 6 cases (12%). The involvement of both margins was significantly associated with rectal tumors and tumors with infiltrative gross appearance, grade III, deeper invasion, and positive lymph node metastases. Also, there was a significant association between both margins’ positivity and other pathological parameters as signet ring carcinoma, tumor budding, perineural and vascular invasion, high microvessel density (MVD), and sinusoidal vascular pattern, while the presence of necrosis and infiltrative advancing tumor front was significantly associated with CRM involvement only. The depth of tumor invasion and signet ring carcinoma were identified as independent predictor factors for positive CRM and LRM, respectively. Conclusion. Preoperative identification of these pathological parameters can be a guide to tailor the management plan accordingly.
机译：背景。圆周切除缘（CRM）和纵向切除缘（LRM）的恶性累及结直肠癌（CRC）外切除后的术后较高的复发率和远处转移的发育。这可以影响整体患者的预后。目前研究的目的是识别病理因素作为预测因子，以预测在T3 CRC早期的切除边缘。患者和方法。在研究中纳入过滤诊断为具有CT3A / B（CRC）的五十名患者。切除后，进行病理检查以鉴定阳性CRM和/或LRM的患者。评估了不同病理参数与CMR和LRM参与的关系。结果。阳性CRM存在于17例（34％）中存在，而6例（12％）发现阳性LRM。两个边缘的累及与直肠肿瘤和肿瘤具有显着相关的渗透性外观，III级，更深的侵袭和阳性淋巴结转移。此外，阳性阳性和其他病理参数之间存在重大关联作为标志癌癌，肿瘤芽，肿瘤和血管侵袭，高微血管密度（MVD）和正弦血管图案，而恶化和渗透前进肿瘤的存在前面只与CRM参与有关。肿瘤侵袭和标志环癌的深度分别被鉴定为阳性CRM和LRM的独立预测因素。结论。这些病理参数的术前识别可以是相应地定制管理计划的指南。

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