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首页> 外文期刊>Italian Journal of Medicine >The role of endothelial dysfunction and inflammation in young-onset hypertension
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The role of endothelial dysfunction and inflammation in young-onset hypertension

机译：内皮功能障碍和炎症在幼小发病高血压中的作用

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Young-onset hypertension is defined as hypertension seen in patients under 40 years of age. The relationship between hypertension and inflammation has been identified. In hypertensive patients, YKL-40 has been shown to be increased by endothelial dysfunction as a local secreted mediator. Vaspin, an adipokine, is derived from adipose tissue and irreversibly inhibits serine proteases. It has been reported that vaspin may act as an anti-inflammatory agent and increases endothelial-dependent relaxation, also has a positive effect on nitric oxide bioavailability, which is important in the etiology of endothelial dysfunction. In clinical practice, some indirect and practical methods may help to evaluate endothelial functions, including flow-mediated dilatation (FMD), which is considered to be the most practical and effective method. The present study was performed to determine the circulating YKL-40 and vaspin levels in young-onset hypertensive patients and healthy subjects and to reveal their relationships with vascular function evaluated by FMD.We enrolled 24 patients diagnosed with young-onset hypertension and 22 volunteers without hypertension. The plasma levels of YKL-40 and vaspin were determined using an enzyme-linked immunosorbent assay and quantitative enzyme-linked immunoassay, respectively. FMD was measured using a Doppler ultrasound device. Compared with those in normotensive controls, the plasma levels of YKL-40 were significantly higher, and FMD values were significantly lower in patients with young-onset hypertension (P0.05). The plasma levels of YKL-40 were also negatively correlated with FMD. However, no statistically significant difference was noted in the levels of vaspin between the two groups (P=0.531). In this study, decreased FMD and increased levels of YKL-40 were associated with endothelial dysfunction and inflammation in patients with young-onset hypertension, suggesting the role of these factors in the etiology of hypertension.
机译：幼眼的高血压被定义为40岁以下患者的高血压。已经确定了高血压与炎症之间的关系。在高血压患者中，已显示YKL-40通过内皮功能障碍增加作为局部分泌的介体。 vaspin是一种己岛，衍生自脂肪组织，不可逆地抑制丝氨酸蛋白酶。据报道，Vaspin可以充当抗炎剂并增加内皮依赖性弛豫，对一氧化氮生物利用度产生积极影响，这在内皮功能障碍的病因中是重要的。在临床实践中，一些间接和实际方法可能有助于评估内皮功能，包括流动介导的扩张（FMD），这被认为是最实用和有效的方法。进行本研究以确定幼苗高血压患者和健康受试者中的循环YKL-40和VASPIN水平，并揭示其与FMD评估的血管功能的关系。我们注册了24名患者，诊断出患有年幼的高血压和22名志愿者，没有高血压。使用酶联免疫吸附测定和定量酶联免疫测定法测定YK1-40和Vaspin的血浆水平。使用多普勒超声装置测量FMD。与规范控制中的那些相比，YKL-40的血浆水平显着较高，患有幼小发病高血压患者的FMD值显着降低（P <0.05）。血浆的YKL-40水平也与FMD负相关。然而，在两组之间的vaspin水平中没有没有统计学显着差异（p = 0.531）。在本研究中，减少的FMD和随着YKL-40的增加水平与患有幼小发病高血压患者的内皮功能障碍和炎症有关，表明这些因素在高血压病因中的作用。

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