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What we can do? The risk factors for multi-drug resistant infection in pediatric intensive care unit (PICU): a case-control study

机译:我们能做什么?儿科重症监护单位多毒性感染的危险因素(PICU):一种案例对照研究

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The risk factors for multi-drug resistant infection (MDRI) in the pediatric intensive care unit (PICU) remain unclear. It’s necessary to evaluate the epidemiological characteristics and risk factors for MDRI in PICU, to provide insights into the prophylaxis of MDRI clinically. Clinical data of 79 PICU children with MDRI were identified, and 80 children in PICU without MDRI in the same period were selected as control group. The related children’s characteristics, clinical care, microbiologic data, treatments provided, and outcomes of the patients with were reviewed and collected. Univariate and multivariate logistic regression analyses were performed to identify the potential risks of MDRI in PICU. Of the diagnosed 79 cases of MDRI, there were28 cases of CR-AB, 24 cases of MRSA, 22 cases of PDR-PA,3 cases of VRE and 2 cases of CRE respectively. Univariate analyses indicated that the length of PICU stay, the duration of mechanical ventilation ?5?days, parenteral nutrition, coma, urinary catheter indwelling, invasive operation, 2 or more antibiotics use were associated with MDRIs (all p 5?days were independent risk factors associated with MDRI (all p??0.05). This present study has identified several potentially modifiable risk factors for MDRI in PICU, it’s conducive to take appropriate measures targeting risk factors of MDRI for health care providers to reduce MDRI.
机译:儿科重症监护单位(PICU)中多药物抗性感染(MDRI)的危险因素仍不清楚。有必要评估PICU中MDRI的流行病学特征和危险因素,临床上提供对MDRI预防的见解。鉴定了79家PICU儿童的临床资料,并选择了80名没有MDRI的PICU儿童作为对照组。综述和收集了相关的儿童特征,临床护理,微生物学数据,提供的治疗和患者的结果。执行单变量和多变量逻辑回归分析,以确定PICU中MDRI的潜在风险。在诊断出79例MDRI患者中,有28例CR-AB,24例MRSA,22例PDR-PA,3例VRE和2例CRE。单变量分析表明,PICU保持的长度,机械通气的持续时间>?5?天,肠胃外营养,昏迷,尿导管留置,侵入性操作,2或更多抗生素使用与MDRIS有关(所有P 5?天是独立的与MDRI相关的风险因素(所有P?<?0.05)。本研究已经确定了PICU中MDRI可能可修改的危险因素,有利于采取适当措施,针对医疗保健提供者的危险因素来减少MDRI。

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