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首页> 外文期刊>Iranian Journal of Microbiology >Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards
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Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

机译：新生儿筛查先天性越来越先天性患者在德黑兰，伊朗，使用Guthrie牌

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Background and Objectives: Cytomegalovirus (CMV) constitutes the most common viral cause of congenital infections in newborns worldwide. There are a significant number of asymptomatic newborns with congenital CMV infection in Iran, which may develop long-term sequelae of infection. Unfortunately, limited data exsists from Iran on the rate of congenital CMV infection among neonates. The current study was aimed to investigate the prevalence of congenital CMV infection among Iranian neonates by testing Guthrie cards. Materials and Methods: Guthrie cards were collected from infants within 2 weeks of life, and total DNA was extracted from samples by thermal shock and evaluated for CMV DNA using nested-PCR assay. CMV infection in newborns was confirmed through a commercial CMV PCR kit. Infected infants underwent further evaluation at the hospital. Results: CMV infection was identified in four of 1174 infants (0.34%) which is approximately 3 cases per 1000 live births. Infected infants were asymptomatic at birth and had a normal hearing status similar to other children. There were no factors in relation with CMV infection among newborns. Conclusion: According to the results of this study, infected infants with congenital CMV infection could identify at early stage by testing Guthrie cards (within 21 days of life). Furthermore, since there is a lack of CMV knowledge in our population, educating and effective counseling by obstetricians/ gynecologists to the pregnant women are recommended.
机译：背景和目标：巨细胞病毒（CMV）构成全球新生儿中先天性感染的最常见的病毒原因。伊朗先天性CMV感染有很大数量的无症状新生儿，这可能会产生长期感染后遗症。不幸的是，来自伊朗的有限数据出版物对新生儿中先天性CMV感染的速率。目前的研究旨在通过测试Guthrie卡来研究伊朗新生儿中先天性CMV感染的患病率。材料和方法：从寿命2周内从婴儿收集Guthrie卡，通过热冲击从样品中提取总DNA，并使用巢式PCR测定评估CMV DNA。新生儿CMV感染通过商业CMV PCR套件确认。受感染的婴儿在医院进行了进一步的评估。结果：CMV感染在1174名婴儿中的四种（0.34％）中鉴定，约为每1000个活产的3例。受感染的婴儿在出生时是无症状的，并且具有与其他孩子相似的正常听力状态。与新生儿中的CMV感染有关没有因素。结论：根据本研究的结果，通过先天性CMV感染的感染婴儿可以通过测试Guthrie卡（生命的21天内）来识别早期阶段。此外，由于我们的人口缺乏CMV知识，建议支持妇产科医生/妇科医生的教育和有效咨询。

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