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Efficacy and safety of carbon dioxide insufflation versus air insufflation during endoscopic retrograde cholangiopancreatography in randomized controlled trials: a systematic review and meta-analysis

机译:在随机对照试验中的内窥镜逆行胆管膜凝视期间二氧化碳吹蛋的功效和安全性与空气吹入性:系统评价和荟萃分析

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Background and study aims Ambient air is the most commonly used gas for insufflation in endoscopic procedures worldwide. However, prolonged absorption of air during endoscopic examinations may cause pain and abdominal distension. Carbon dioxide insufflation (COsub2/subi) has been increasingly used as an alternative to ambient air insufflation (AAi) in many endoscopic procedures due to its fast diffusion properties and less abdominal distention and pain. For endoscopic retrograde cholangiopancreatography (ERCP), use of COsub2/sub for insufflation is adequate because this procedure is complex and prolonged. Some randomized controlled trials (RCTs) have evaluated the efficacy and safety of COsub2/sub as an insufflation method during ERCP but presented conflicting results. This systematic review and meta-analysis with only RCTs evaluated the efficacy and safety of COsub2/subi versus AAi during ERCP. Methods A literature search was performed using online databases with no restriction regarding idiom or year of publication. Data were extracted by two authors according to a predefined data extraction form. Outcomes evaluated were abdominal pain and distension, complications, procedure duration, and COsub2/sub levels. Results Eight studies (919 patients) were included. Significant results favoring COsub2/subi were less abdominal distension after 1?h (MD: ?1.41 [?1.81; ?1.0], 95?% CI, I2?=?15?%, P ?0.00001) and less abdominal pain after 1?h (MD: ?23.80 [?27.50; ?20.10], 95?%CI, I2?=?9?%, P ?0.00001) and after 6?h (MD: ?7.00 [?8.66; ?5.33]; 95?% CI, I2?=?0?%, P ?0.00001). Conclusion Use of COsub2/subi instead of AAi during ERCP is safe and associated with less abdominal distension and pain after the procedure.
机译:背景和研究目标环境空气是全球内窥镜手术中最常用的气体。然而,在内窥镜检查期间延长空气吸收可能会导致疼痛和腹胀。由于其快速扩散性能和腹部偏差和疼痛较小,二氧化碳吹入(CO 2 I)越来越多地用作环境空气吹蛋(AAI)的替代方案,并且腹胀较小。对于内窥镜逆行胆管胆管痴呆(ERCP),使用CO 2 用于吹塑的用途是足够的,因为该程序复杂并延长。一些随机对照试验(RCT)已经在ERCP期间评估了CO 2 作为灭吸方法的疗效和安全性,但呈现了相互矛盾的结果。这种系统审查和荟萃分析仅具有RCT,评估了CO 2 i与AAI期间的疗效和安全性。方法使用在线数据库执行文献搜索,没有关于成语或发布年的限制。根据预定义的数据提取形式,由两个作者提取数据。结果评估的结果是腹痛和扩张,并发症,程序持续时间和CO 2 水平。结果包括八项研究(919名患者)。优化Co 2 1的显着成果在1°(MD:α1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1.1%,I2?=?15?%,P <? 0.00001)和1?H后腹痛较少(MD:23.80 [27.50;〜20.10],95〜%CI,I2?=?9?%,P <0.000000)和6?H(MD:? 7.00 [?8.66;?5.33]; 95?%CI,I2?= 0?%,P <0.00001)。结论在ERCP期间使用CO 2 I代替AAI是安全的,在手术后腹胀和疼痛较小。

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