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首页> 外文期刊>Endoscopy International Open >Pancreatic sphincterotomy improves pain symptoms due to branch-duct intrapapillary mucinous neoplasia without worrisome features: a multicenter study
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Pancreatic sphincterotomy improves pain symptoms due to branch-duct intrapapillary mucinous neoplasia without worrisome features: a multicenter study

机译：胰腺括约肌术改善疼痛症状由于薄膜管薄膜粘液瘤瘤，没有令人担忧的特点：多中心的研究

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Introduction?Branch duct intraductal papillary mucinous neoplasms (BD-IPMNs) require follow-up to detect worrisome features (WF). Data are missing about endoscopic pancreatic sphincterotomy (PS) for symptomatic IPMN. Patients and methods?This was a retrospective multicenter study in four expert centers. Patients treated with endoscopic PS for symptomatic (painful) BD-IPMN without WF were included. Age, sex, follow-up time, characteristics of IPMNs and endoscopic retrograde cholangiopancreatographies (ERCPs), and indications for surgery were recorded. Results?In total, 21 patients were included (median age 68 years, range 45?–?87 years). The median number of cysts was 2 (range 1?–?10), located in the head (59?%), body/tail (17?%), or multifocal (24?%). ERCP including PS was completed in all of the cases, with biliary sphincterotomy in 33?%. Clinical efficacy after one session was 81?% (17/21). Among the failures, one had a second successful PS and three were operated. The final efficacy was 86?% (18/21). Seven patients were operated after a mean of 19 months: four for WF, three for pain. The histopathology showed four low grade dysplasia, one high grade dysplasia, and two no dysplasia. No adenocarcinoma occurred during a follow-up of 99 months (range 14?–?276 months). Conclusions?Endoscopic PS for symptomatic IPMN without WF is effective in more than 80?% of cases, without increasing the risk for adenocarcinoma.
机译：介绍？分支管道管内乳头状乳酸肿瘤（BD-IPMNS）需要随访以检测令人担忧的特征（WF）。关于内窥镜胰丝括约肌术（PS）的数据缺失数据，用于症状IPMN。患者和方法？这是四个专家中心的回顾性多中心研究。包括症状（疼痛）对症状（疼痛）BD-IPM治疗的患者，没有WF。记录了年龄，性别，随访时间，IPMNS和内窥镜逆行胆管偶联（ERCP）的特征，以及手术的适应症。结果？总共包括21例患者（中位年龄68岁，范围45？ - ？87岁）。位于头部（59Ω％），体/尾（17Ω％）或多焦点（24μm）中，囊肿中值为2（范围1？ - α10）。在包括PS的ERCP在所有病例中完成，胆道括约肌细胞术33？％。一个会议后的临床疗效为81次（17/21）。在失败中，一个人有第二次成功的PS，三个被运营。最终疗效为86？％（18/21）。在19个月的平均值后，七名患者进行操作：WF，三个用于疼痛。组织病理学表现出四种低等级的发育不良，一个高等级的发育不良，两种没有发育不良。在99个月的随访期间没有发生腺癌（范围14？ - 276个月）。结论？没有WF的症状IPMN的内窥镜PS在超过80？％的病例中有效，而不增加腺癌的风险。

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