Background and study aims?Ileocecal valve (ICV) lesions are challenging to remove endoscopically. Patients and methods?This was a retrospective cohort study, performed at an academic tertiary US hospital. Sessile polyps or flat ICV lesions ≥?20?mm in size referred for endoscopic mucosal resection (EMR) were included. Successful resection rates, complication rates and recurrence were compared to lesions ≥?20?mm in size not located on the ICV. Results?During an 18-year interval, there were 118 ICV lesions ≥?20?mm with mean size 28.6?mm (44.9?% females; mean age 71.6 years), comprising 9.03?% of all referred polyps. Ninety ICV lesions (76.3?%) were resected endoscopically, compared to 91.3?% of non-ICV lesions (P?P?=?0.485). At second follow-up residual rates in the ICV and non-ICV lesion groups were 18.6?% and 6.7?%, respectively (P?=?.005). Conclusions?Large ICV polyps are a common source of tertiary referrals. Over an 18-year experience, risk of EMR for ICV polyps was numerically lower, and risk of recurrence was numerically higher at first follow and significantly higher at second follow-up compared to non-ICV polyps.
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