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首页> 外文期刊>Endoscopy International Open >A novel endoscopic imaging system for quantitative evaluation of colonic mucosal inflammation in patients with quiescent ulcerative colitis
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A novel endoscopic imaging system for quantitative evaluation of colonic mucosal inflammation in patients with quiescent ulcerative colitis

机译：一种新型内镜成像系统，用于静态溃疡性结肠炎患者结肠粘膜炎症的定量评价

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Background and study aims?Mucosal healing (MH) is associated with clinical outcome in ulcerative colitis (UC) patients. In most clinical trials, a Mayo endoscopic subscore (MES) of 0 or 1 is defined as MH. However, several recent studies have reported that clinical outcome is different between UC patients with MES 0 and those with MES 1. In addition, the MES is subjective and may differ among endoscopists. Therefore, a repeatable and objective scoring system is required to distinguish MES 0 from MES 1, even in clinically quiescent UC. Here, we assessed the usefulness of new image-enhancing endoscopic technology, the i-scan TE-c, to quantitatively evaluate colonic inflammation in patients with quiescent UC. Methods?We retrospectively reviewed the data from 52 UC patients in clinical remission who had undergone routine colonoscopy with standard white light. The white-light images were reassessed using the new system, and the degree of colonic mucosal inflammation was quantified according to the MAGIC (Mucosal Analysis of Inflammatory Gravity by i-scan TE-c Image) score. We used the i-scan TE-c system to investigate the association among the MAGIC score, MES, and histologic activity (Geboes score). Results?The MAGIC score was significantly higher in the MES 1 group than in the MES 0 group (P?=?0.0034). The MAGIC score significantly correlated with the Geboes score (P?=?0.015). Conclusions?Our novel image-enhancing endoscopic system was useful for objective and quantitative evaluation of MH in patients with quiescent UC. Further clinical studies using this imaging system are required to confirm its clinical benefit for the management of UC patients.
机译：背景和研究旨在？粘膜愈合（MH）与溃疡性结肠炎（UC）患者的临床结果有关。在大多数临床试验中，Mayo内窥镜亚核（MES）为0或1的定义为MH。然而，最近的几项研究报告说，临床结果是UC患者0和MES的患者之间的不同。此外，MES是主观的，可能在内窥镜手中不同。因此，即使在临床上静态UC中，也需要可重复和客观评分系统以将MES 0与MES 1区分开。在这里，我们评估了新的图像增强内窥镜技术，I-Scan TE-C，以静态UC患者定量评估结肠癌的有用性。方法？我们回顾性地审查了52例UC患者的数据，临床缓解患者，患有标准白光经过常规结肠镜检查的临床缓解。使用新系统重新评估白光图像，根据魔法量化结肠粘膜炎症程度（通过I-Scan TE-C图像的炎症重力的粘膜分析）得分。我们使用I-Scan TE-C系统来调查Magic Sc​​ore，MES和组织学活动（Geobes得分）之间的关联。结果？MES 1组中的魔法分数显着高于MES 0组（P？= 0.0034）。魔法分数与易培素分数显着相关（P？= 0.015）。结论？我们的新型图像增强内窥镜系统对于静态UC患者的目标和定量评估MH。使用该成像系统的进一步临床研究是为了确认其临床益处对UC患者的管理。

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