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首页> 外文期刊>Endoscopy International Open >Duodenal mucosal resurfacing: Multicenter experience implementing a minimally invasive endoscopic procedure for treatment of type 2 diabetes mellitus
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Duodenal mucosal resurfacing: Multicenter experience implementing a minimally invasive endoscopic procedure for treatment of type 2 diabetes mellitus

机译：十二指肠粘膜Resurfacing：多中心经验，实施用于治疗2型糖尿病的微创内窥镜手术

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Background and study aims?Duodenal mucosal resurfacing (DMR) is an endoscopic procedure which improves insulin resistant metabolic disease, including type 2 diabetes mellitus (T2DM). The aim of this report was to evaluate the feasibility and procedural aspects of DMR and to provide more specific DMR procedural guidance for endoscopists. Patients and methods?In this international multicenter, prospective, open-label study, patients on oral anti-diabetic agents for treating T2DM?underwent single DMR. DMR entails circumferential submucosal lifting followed by circumferential mucosal hydrothermal ablation using an over-the-guidewire balloon catheter for lifting and ablation. For the first 28 patients a dual catheter system was used. During the study, a new integrated catheter was developed which was used for the latter 18 patients. During DMR, procedure success (complete DMR: duodenal ablation length ≥?9?cm) and procedure duration were captured. Results?Forty-six patients underwent DMR. Using the dual catheter system, a complete DMR was performed in 22 of 28 patients (79?%). In the next eighteen patients who underwent DMR with the integrated catheter, a complete DMR was performed in 15 of 18 patients (83?%). The integrated catheter facilitated the DMR procedure and resulted in a reduction in procedure time. A detailed table and video are provided for future endoscopists. Conclusions?In our multicenter study, DMR was found to be feasible in the hands of experienced endoscopists. The integrated DMR catheter was a welcome modification during the study, allowing for easier ablation administration. Further optimization of the technique would be valuable prior to widespread dissemination.
机译：背景和研究目标？十二指肠粘膜Resurfacing（DMR）是一种内窥镜程序，可改善胰岛素抗性代谢疾病，包括2型糖尿病（T2DM）。本报告的目的是评估DMR的可行性和程序方面，并为内窥镜师提供更具体的DMR程序指导。患者和方法？在这项国际多中心，前瞻性，开放标签研究中，患者对口腔抗糖尿病药剂治疗T2DM？接受单一DMR。 DMR需要圆周粘膜升降，然后使用过导丝球囊导管来提升和消融的周向粘膜水热消融。对于前28名患者，使用双导管系统。在研究期间，开发了一种新的综合导管，用于后者18例。在DMR期间，程序成功（完整DMR：十二指肠消融长度≥≤9Ωcm）和过程持续时间。结果？46名患者接受了DMR。使用双导管系统，在22例患者中进行完整的DMR（79℃）。在接下来的十八名与集成导管接受DMR的患者中，在18名患者的15名（83岁）中进行完整的DMR。集成导管促进了DMR程序，导致程序时间减少。为未来的内窥镜师提供了详细的表和视频。结论？在我们的多中心研究中，DMR被发现在经验丰富的内窥镜手中可行。集成的DMR导管是在研究期间进行的欢迎改造，允许更容易消融给药。在广泛传播之前，该技术的进一步优化将是有价值的。

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