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首页> 外文期刊>Endocrinology, Diabetes & Metabolism >Assessment of the high risk and unmet need in patients with CAD and type 2 diabetes (ATHENA): US healthcare resource utilization, cost and burden of illness in the Diabetes Collaborative Registry
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Assessment of the high risk and unmet need in patients with CAD and type 2 diabetes (ATHENA): US healthcare resource utilization, cost and burden of illness in the Diabetes Collaborative Registry

机译：CAD患者和2型糖尿病（ATHENA）评估高风险和未满足的需求：美国医疗保健资源利用，糖尿病协作登记处的疾病成本和伤害

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Background THEMIS (NCT01991795) showed that in patients with type 2 diabetes (T2D) and stable coronary artery disease (CAD) but with no prior myocardial infarction (MI) or stroke, ticagrelor plus acetylsalicylic acid (ASA) decreased the incidence of ischaemic cardiovascular events compared with placebo plus ASA. To complement these findings, we assessed disease burden and healthcare resource utilization (HRU) in US patients with CAD and T2D, but without a prior MI or stroke. Methods This observational study used 2013‐2014 data from the Diabetes Collaborative Registry linked to Medicare administrative claims. Two cohorts of patients with T2D were studied: patients at high cardiovascular risk (THEMIS‐like cohort; N?=?56?040) and patients at high cardiovascular risk or taking P2Y12 inhibitors (CAD‐T2D cohort; N?=?69?790). Outcomes included the composite of all‐cause death, MI and stroke; the individual events from the composite endpoint; HRU; and costs. Results Median age was 73.0?years, and median follow‐up was 1.3?years in both cohorts. Event rates of the composite outcome were 16.34 (95% confidence interval: 16.31‐16.37) and 17.64 (17.61‐17.67) per 100 person‐years for the THEMIS‐like and CAD‐T2D cohorts, respectively. The incidence rate of bleeding events was 0.13 events per 100 person‐years in both cohorts. Healthcare costs per patient‐year were USD 8741 and USD 9150 in the THEMIS‐like and CAD‐T2D cohorts, respectively. Conclusions Patients in the THEMIS‐like cohort and the broader CAD‐T2D population had similarly substantial cardiovascular event rates and healthcare costs, indicating that patients with CAD and T2D similar to the THEMIS population are at an increased cardiovascular risk.
机译：背景技术（NCT01991795）显示，在2型糖尿病（T2D）和稳定的冠状动脉疾病（CAD）中，但没有现有的心肌梗死（MI）或中风，TicagreloL加上乙酰胱氨酸（ASA）降低了缺血性心血管事件的发生率与安慰剂加上asa相比。为了补充这些调查结果，我们评估了美国CAD和T2D患者的疾病负担和医疗资源利用（HRU），但没有先前的MI或中风。方法本发明学研究使用2013-2014来自糖尿病协作登记处的数据与Medicare行政索赔相关。研究了T2D患者的两群患者：患者高血管造风险（题为群体; N？=？56？040）和高心血管风险或服用P2Y12抑制剂的患者（CAD-T2D COSHORT; N？= 69？ 790）。结果包括全因死亡，mi和中风的综合;复合端点的个别事件; hru;和成本。结果中位年龄为73.0年龄？年龄，中位随访是1.3？两年的队列。综合结果的事件率分别为16.34（95％置信区间：16.31-16.37）和17.64（17.61-17.67），分别为主题和CAD-T2D队列的每100人。出血事件的发生率为每100人在两个队列中的0.13个事件。在主题和CAD-T2D队列中，每位患者年份的医疗费用为8741美元和9150美元。结论患者在主题的群体和更广泛的CAD-T2D群体中具有同样大量的心血管事件率和医疗成本，表明CAD和T2D的患者类似于主题人群的心血管风险增加。

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