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首页> 外文期刊>Journal of diabetes and its complications >The burden of hypoglycemia on healthcare utilization, costs, and quality of life among type 2 diabetes mellitus patients
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The burden of hypoglycemia on healthcare utilization, costs, and quality of life among type 2 diabetes mellitus patients

机译：低血糖对2型糖尿病患者的医疗保健利用率，成本和生活质量的负担

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Objective: To assess the burden of hypoglycemia among type 2 diabetes patients on antidiabetic drugs with or without use of insulin. Research Design and Methods: We used mail surveys, administrative claims data, and enrollment information from a sample of adult commercial health plan enrollees (n = 813) with type 2 diabetes during a 12-month period. Patients' experience of hypoglycemia, its impact on patient perspectives and healthcare utilization were the outcomes evaluated. Results: A greater percentage of patients in the antidiabetic with insulin cohort reported experiencing hypoglycemia compared with patients from sulfonylurea (SU) without insulin and non-SU without insulin cohorts (50% vs. 21% and 12%, respectively; p < 0.01 for both comparisons). While 71% of the sample reported experiencing hypoglycemic symptoms with 28% confirmed by low blood glucose levels, only 10% of the patients had evidence of hypoglycemia event in the claims database. Patients with confirmed hypoglycemia had the highest Hypoglycemia Fear Survey behavior score (8) and worry subscale score (14). Significant differences were noted between the confirmed hypoglycemia and no hypoglycemia cohorts for the 12-item Short Form Health Survey's Mental Component Score (p < 0.001) and Physical Component Score (p = 0.002), and for the EQ-5D index (p < 0.001). Diabetes-related annualized mean total healthcare costs were significantly higher for confirmed hypoglycemia vs. no hypoglycemia cohorts (p = 0.004). Conclusions: Symptomatic hypoglycemia is a more significant burden among type 2 diabetes patients treated with antidiabetic drugs than is estimated by administrative claims data and needs to be considered when choosing therapy.
机译：目的：评估使用或不使用胰岛素的抗糖尿病药物对2型糖尿病患者的低血糖负担。研究设计和方法：我们使用了邮件调查，行政索赔数据和12个月内患有2型糖尿病的成人商业健康计划参与者（n = 813）的样本中的登记信息。评估患者的低血糖经历，其对患者观点的影响和医疗保健利用率。结果：与未使用胰岛素的磺脲类药物（SU）和未使用胰岛素的非SU组相比，患有胰岛素队列的抗糖尿病患者中发生低血糖的比例更高（分别为50％，21％和12％; p <0.01两个比较）。虽然71％的样本报告有降血糖症状，其中28％的血糖水平低，但在索赔数据库中只有10％的患者有低血糖事件的证据。确诊为低血糖的患者低血糖恐惧调查行为评分最高（8），焦虑量表评分最高（14）。在12项简短形式健康调查的心理成分得分（p <0.001）和身体成分得分（p = 0.002）和EQ-5D指数（p <0.001）的确诊的低血糖人群与无低血糖人群之间，存在显着差异。 ）。确诊的低血糖患者与糖尿病相关的年平均总医疗保健费用明显高于无低血糖人群（p = 0.004）。结论：在抗糖尿病药物治疗的2型糖尿病患者中，症状性低血糖的负担比行政要求数据所估计的更为严重，因此在选择治疗方法时应予以考虑。

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