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首页> 外文期刊>Endocrine journal >Characteristics of Prolactin Secretion in Normal and Estrogen-Treated Pituitaries of Rats at the Single Cell Level
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Characteristics of Prolactin Secretion in Normal and Estrogen-Treated Pituitaries of Rats at the Single Cell Level

机译：单细胞水平正常和雌激素治疗大鼠正常雌激素分泌的特征

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References(24) Cited-By(1) We studied PRL release from individual pituitary cells in normal and estrogen (E2)-treated female Fischer 344 rats by means of a reverse hemolytic plaque assay. In this assay, the area of the hemolytic plaque around a pituitary cell is proportional to the amount of hormone secreted from the cell. Multimodal distribution of the plaque area was observed in normal pituitary cells, and was unchanged in the course of aging. In E2-treated pituitary cells, bimodal distribution was found. The heterogeneity of the distribution pattern (functional heterogeneity) and PRL secretion from a single pituitary cell decreased in association with the length of E2 treatment. The mean plaque area for the E2-treated pituitary cells was smaller than that for the normal pituitary cells. These results suggest that in E2-treated pituitary cells, the functional heterogeneity and PRL release from a single cell decrease as tumorigenesis progresses.
机译：引用（24）引用（1）通过逆转溶血法测定，从正常和雌激素（E2） - 治疗的雌性Fischer 344大鼠中的个体垂体细胞中研究了PRL释放。在该测定中，垂体细胞周围的溶血性斑块的面积与来自细胞分泌的激素的量成比例。在正常的垂体细胞中观察到斑块区域的多峰分布，在衰老过程中没有变化。在E2处理的垂体细胞中，发现双峰分布。与e2处理的长度相关联的分布图（功能异质性）和PRL分泌物的异质性降低。 E2处理垂体细胞的平均斑块区域小于正常垂体细胞的平均斑块区域。这些结果表明，在E2处理的垂体细胞中，随着肿瘤发生的进展，从单细胞的功能异质性和PRL释放。

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