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首页> 外文期刊>Epilepsy & Seizure >An elderly case of consciousness disturbance due to levetiracetam and low doses of carbamazepine
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An elderly case of consciousness disturbance due to levetiracetam and low doses of carbamazepine

机译：Levetiracetam和低剂量患有levetiracetam的老年人障碍的病例

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It is challenging to discern whether consciousness disturbances experienced by an epilepsy patient are due to insufficient pharmacological activity of antiepileptic drugs or medication side effects. We treated an 82-year-old man with epilepsy who experienced a cerebellar infarction, followed by renal impairment due to a right renal infarction, and had decreased serum albumin levels. His consciousness disturbance persisted for more than two months. The disturbance improved one day after termination of levetiracetam administration. Re-administration of levetiracetam resulted in recurrence of consciousness disturbance. When carbamazepine was administered, he experienced consciousness disturbance despite a low blood concentration of 3.0 μg/mL. Drug-monitoring methods are well established for carbamazepine, but levetiracetam is a novel antiepileptic drug. This case report suggests that in patients with renal impairment and hypoalbuminemia, levetirace-tam and low doses of carbamazepine may cause sporadic adverse effects such as consciousness disturbance.
机译：辨别癫痫患者是否经受抗癫痫药物或药物副作用的药理活性不足是挑战的挑战。我们对一名82岁的人患有癫痫，癫痫患者经历了小脑梗死，随后由于肾脏梗死的肾脏梗死，并且血清白蛋白水平降低。他的意识障碍持续了两个多个月。在左旋雷替金属给药终止后，扰动改善了一天。重新施用Levetiracetam导致意识障碍的复发。施用卡马米血珠时，尽管血液浓度为3.0μg/ ml，但他经历了意识障碍。药物监测方法对于卡马柳氏菌，但Levetiracetam是一种新型抗癫痫药物。本案例报告表明，在肾损伤和低稳压血症患者中，LeveTirace-TAM和低剂量的卡巴马嗪可能导致散发性不良反应，例如意识障碍。

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