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首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Ameliorative effects of ginger and -lipoic acid on oxidative stress and inflammation in senile female rats
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Ameliorative effects of ginger and -lipoic acid on oxidative stress and inflammation in senile female rats

机译：生姜和 - - 乙酸对老年女大鼠氧化应激和炎症的改善作用

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Oxidative stress is recognized as an important environmental factor in aging. The reactive oxygen species and related free radicals are normally produced both intra and extracellular and air-breathing organisms cannot avoid the risk of oxidative stress. Moreover, recent studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In the present study, the evaluation of the protective effects of ginger and α-lipoic acid (ALA) supplementation on senile female rats is evaluated during inflammation. The results showed a significant increase in lipid peroxidation but a significant reduction in the reduced glutathione level (GSH), the activities of superoxide dismutase (SOD), catalase (CAT) and cytochrome P450 (CytoP450) in hepatic aged female rats. In addition, this study revealed a significant increase in the inflammatory mediators interlukin-1(IL-1), interlukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) as well as the activity of cyclooxygenase enzyme (COX-2). Furthermore, there was a significant decrease in serum nitric oxide (NO) in aged female rats. Ginger and ALA were effective in minimizing aged-related oxidative burden through decreasing lipid peroxidation, increasing GSH content and promoting antioxidant enzymes. Moreover, the compounds under investigation reduced the levels of the pro-inflammatory cytokines IL-1, IL-6 and TNF-α, in addition to inhibiting the activity of COX-2. The levels of serum NO was also increased by the treatments.
机译：氧化应激被认为是老化的重要环境因素。反应性氧物质和相关的自由基通常产生内部和细胞外，空气呼吸的生物体不能避免氧化应激的风险。此外，最近的研究已经提出了慢性炎症的观念作为衰老和年龄相关疾病的主要危险因素。在本研究中，在炎症期间评估了对姜和α-硫辛酸（ALA）对老年雌性大鼠的保护作用的评价。结果表明，脂质过氧化的显着增加，但降低了谷胱甘肽水平（GSH）的显着降低，超氧化物歧化酶（SOD），过氧化氢酶（CAT）和肝脏雌性大鼠中的细胞色素P450（Cytop450）的活性。此外，该研究表明，炎症介质介质-1（IL-1），白细胞蛋白-6（IL-6），肿瘤坏死因子α（TNF-α）以及环氧氧酶酶的活性（COX -2）。此外，在老年的雌性大鼠中存在血清一氧化氮（NO）的显着降低。姜和ALA通过降低脂质过氧化，增加GSH含量和促进抗氧化酶，从而使老年相关的氧化负担有效。此外，除了抑制COX-2的活性之外，正在研究的化合物还降低了促炎细胞因子IL-1，IL-6和TNF-α的水平。治疗也增加了血清的水平。

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