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首页> 外文期刊>European Heart Journal - Case Reports >Drug-induced ‘Torsade de Pointes’ in a COVID-19 patient despite discontinuation of chloroquine. Importance of its long half-life: a case report
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Drug-induced ‘Torsade de Pointes’ in a COVID-19 patient despite discontinuation of chloroquine. Importance of its long half-life: a case report

机译：尽管停止氯喹，但在Covid-19患者中诱导的药物引起的“扭转DE指向”。其长半衰期的重要性：案例报告

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Background Early studies have led to the repositioning of a subgroup of antimalarial agents (e.g. chloroquine and hydroxychloroquine) as antiviral treatment in coronavirus disease 2019 (COVID-19) patients. These drugs are now being prescribed based on small non-controlled studies, but larger controlled studies have yet to demonstrate the positive effect of these drugs. In addition, these drugs are also known for their QT interval-prolonging effect associated with significant morbidity and mortality. Case summary We present a case of a 66-year-old female admitted to the intensive care unit with respiratory failure due to COVID-19. She was treated with chloroquine (QTc interval at baseline was 429 ms). Despite cessation of chloroquine, but after the start of erythromycin, she developed severe QTc interval prolongation (QTc interval 550 ms) and ‘Torsade de Pointes’. Two weeks after cessation of all QTc interval-prolonging drugs, the QTc interval was restored. Discussion The elimination half-life of chloroquine ranges from days up to weeks. Even after discontinuation of chloroquine, ECG monitoring in COVID-19 patients is warranted. We recommend observation of the QT interval after cessation of chloroquine in cases where other potentially QT interval-prolonging drugs are introduced.
机译：背景技术早期研究导致重新定位冠状病毒疾病2019（Covid-19）患者抗病毒治疗的抗疟剂（例如氯喹和羟氯喹）的重新定位。这些药物正在根据小型非受控研究规定，但较大的受控研究尚未证明这些药物的积极作用。此外，这些药物也已知其与显着发病率和死亡率相关的QT间隔延长效果。案例摘要我们提出了一个66岁女性的案例，该女性录取了强化护理单元，由于Covid-19，呼吸失败。她被氯喹对待（基线时的QTC间隔为429毫秒）。尽管氯喹停止，但在红霉素开始后，她开发出严重的QTC间隔延长（QTC间隔550毫秒）和“扭转de pointes”。停止后两周延长所有QTC间隔延长药物，QTC间隔恢复。讨论消除氯喹的半衰期从几周到几周的时间。即使在停止氯喹之后，Covid-19患者中的ECG监测也受到了保证。我们建议观察氯喹在菌丝停止后的QT间隔，其中引入其他潜在的QT间歇性药物。

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