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首页> 外文期刊>European review for medical and pharmacological sciences. >Beneficial therapeutic effects of hemoperfusion in the treatment of severe Stevens-Johnson syndrome/toxic epidermal necrolysis: preliminary results
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Beneficial therapeutic effects of hemoperfusion in the treatment of severe Stevens-Johnson syndrome/toxic epidermal necrolysis: preliminary results

机译：血液灌注治疗严重史蒂文森综合征/毒性表皮坏死的有益治疗效果：初步结果

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OBJECTIVE: Most of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug eruptions. There is currently no established treatment due to a lack of controlled/blinded studies. High-dose glucocorticoids and intravenous immunoglobulins (IVIG) therapy have been widely used, but these approaches remain controversial. This study introduces a novel method by which to treat severe SJS/TEN patients who were refractory to glucocorticoids and IVIG. PATIENTS AND METHODS: Seven patients with SJS and three patients with TEN were enrolled in this non-blinded, uncontrolled study. The average patient age was 8.1 years. The male to female ratio was 1:1. Hemoperfusion was conducted daily using a HA280 resin sorbent column until new skin lesions ceased appearing and the skin started healing with visible re-epithelialization. RESULTS: The average BSA involvement in SJS and TEN was 8.57% and 75%, respectively. The number of hemoperfusion sessions ranged from 3 to 5. Hemoperfusion led to prompt improvements in general health and halted the disease progression. All children were discharged and recovered completely. The average length of stay was 14.4 days. Four patients experienced adverse reactions: femoral vein thrombosis (N = 2), hypotension (N = 1), and cardiac palpitation (N = 1). CONCLUSIONS: Hemoperfusion may be a useful adjunct treatment for patients with severe SJS/TEN if the initial treatment with glucocorticoids and IVIG fails.
机译：目的：大多数史蒂文斯 - 约翰逊综合征（SJ）和有毒表皮坏死（十）是严重的药物爆发。由于缺乏受控/盲目的研究，目前没有建立的治疗。已广泛使用高剂量糖皮质激素和静脉内免疫球蛋白（IVIG）治疗，但这些方法仍然存在争议。本研究介绍了一种新的方法，可以治疗严重的SJ / 10名患者，他们是糖皮质激素和IVIG的难治性。患者及方法：患有SJ和三名患者的患者，注册了这种非盲目的，不受控制的研究。平均患者年龄为8.1岁。男性与女性比例为1：1。每天使用HA280树脂吸附剂柱进行血液灌注，直至出现新的皮肤病变，并且皮肤开始用可见的重新上皮化进行愈合。结果：平均BSA参与SJ和十个分别为8.57％和75％。血液灌注会话的数量范围为3至5.血液灌注，以迅速提高一般健康，并停止疾病进展。所有孩子都被排出并完全恢复。平均逗留时间为14.4天。四名患者经历不良反应：股静脉血栓形成（n = 2），低血压（n = 1），和心悸（n = 1）。结论：如果糖皮质激素和IVIG的初始治疗失败，血液灌注可能是严重SJS / T1患者的有用辅助治疗。

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