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首页> 外文期刊>European review for medical and pharmacological sciences. >Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus
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Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus

机译：二甲双胍通过影响用链脲佐菌素诱导的2型糖尿病大鼠的大鼠血清总胆汁酸水平改善葡萄糖和脂质代谢。

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OBJECTIVE: To study the effects of metformin on streptozotocin-induced type 2 diabetes mellitus (T2DM) in rats. MATERIALS AND METHODS: Wistar male rats were divided into two groups: standard diet (SD, n = 20) group and high-fat diet (HFD, n = 80) group. Twenty rats in HFD group were randomly treated with metformin (EI group). After 6 weeks, among rats in HFD group, 20 rats were intraperitoneally injected with citrate buffered saline (IR group), 20 rats treated with metformin per day for 4 weeks (LI group), and 20 rats were given nothing (DM group). Rats in SD group were injected with citrate buffered saline as normal control (NC) group. Moreover, streptozotocin (STZ) was used for inducing diabetes. The metabolic parameters, such as body weight, fasting blood glucose (FBG), fasting insulin concentration (FINS), total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDLC) and total bile acid (TBA) were measured. RESULTS: Compared with SD group, the levels of body weight, FBG, TC, LDLC, TBA and FINS and AUC (glucose) were significantly higher in HFD group. After administration of metformin, the levels of FBG, TG, TC, LDLC and TBA in DM and LI group were higher than NC group. Besides, the FBG, TG, TC, TBA and LDLC levels in EI group were higher than DM group. CONCLUSIONS: Metformin may help to improve the glucose and lipid metabolism by influencing the level of serum total bile acids. A combination of HFD and metformin could be effective in the treatment of rats with T2DM.
机译：目的：研究二甲双胍对大鼠链脲佐菌素诱导的2型糖尿病（T2DM）的影响。材料和方法：Wistar雄性大鼠分为两组：标准饮食（SD，N = 20）组和高脂饮食（HFD，N = 80）组。用二甲双胍（EI组）随机处理HFD组中的20只大鼠。在6周后，在HFD组的大鼠中，用柠檬酸盐缓冲盐水（IR组）腹膜内注射20只大鼠，每天用二甲双胍处理的20只大鼠4周（Li组），并且没有给予20只大鼠（DM组）。将SD组大鼠用柠檬酸盐缓冲盐水作为正常对照（NC）基团注射。此外，链脲佐菌素（STZ）用于诱导糖尿病。代谢参数，如体重，空腹血糖（FBG），空腹胰岛素浓度（翅片），总胆固醇（Tc），总甘油三酯（Tg），低密度脂蛋白胆固醇（LDLC）和总胆汁酸（TBA）测量了。结果：与SD组相比，HFD组中体重，FBG，TC，LDLC，TBA和鳍和AUC（葡萄糖）的水平显着高。在施用二甲双胍之后，DM和LI基团中FBG，Tg，Tc，LdLc和Tba的水平高于Nc基团。此外，EI组的FBG，TG，TC，TBA和LDLC水平高于DM组。结论：二甲双胍可以通过影响血清总胆汁酸水平来帮助改善葡萄糖和脂质代谢。 HFD和二甲双胍的组合可以有效地治疗T2DM的大鼠。

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