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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >The Functional Difference of Dendritic Cells in HBeAg Negative Chronic Hepatitis B Patients with Three Different Spleen Deficiency Syndromes and the Therapeutic Evaluation of Chinese Medicine Intervention Based on Syndrome Differentiation
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The Functional Difference of Dendritic Cells in HBeAg Negative Chronic Hepatitis B Patients with Three Different Spleen Deficiency Syndromes and the Therapeutic Evaluation of Chinese Medicine Intervention Based on Syndrome Differentiation

机译：基于综合征分化的中医干预患者HBEAG阴性慢性乙型肝炎患者的树突状细胞功能差异及中医干预治疗评价

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Objective. To investigate the dendritic cells (DCs) maturity differences of HBeAg negative chronic hepatitis B (CHB) patients with different spleen deficiency (SD) syndromes and explore the role of syndrome differentiation in the therapeutic evaluation of Chinese medicine.Methods. 120 participants were recruited including three treatment groups in different SD syndrome categories as spleen deficiency with liver depression (SDLD), spleen deficiency with damp heat (SDDH), and spleen deficiency with kidney deficiency (SDKD) and one healthy control group; each group had 30 participants. Corresponding drugs were applied. The outcome measures included DC phenotype, liver function, IL-10, IL-12, and HBV-DNA levels.Results.The surface markers of mature DCs and cytokines levels were different in each group; the positive rate of CD80, CD1a, HLA-DR, and CD1a was the lowest in SDKD group. After 3-month intervention, the expression of CD80, CD86, CD1a, HLA-DR, and IL-12 significantly increased, while ALT, AST, and IL-10 significantly decreased (P<0.05) in treatment groups. HBV-DNA level also significantly reduced in both SDKD and SDLD groups (P<0.05).Conclusions.HBeAg negative patients had DCs dysmaturity, and there were differences between different SD syndromes. Chinese medicine intervention according to syndrome differentiation could advance the maturity and function of DCs and improve the therapeutic effect.
机译：客观的。探讨不同脾虚（SD）综合征（SD）综合征（SD）综合征患者HBEAG阴性慢性乙型肝炎（CHB）患者的树突状细胞（DCS）成熟度差异，探讨了综合征分化在中医治疗评价中的作用。招募了120名参与者，包括不同SD综合征类别的三个治疗组，因为肝脏抑郁（SDLD），脾脏缺乏潮湿（SDDH），脾脏缺乏患者（SDKD）和一个健康对照组;每组有30名参与者。应用了相应的药物。结果措施包括DC表型，肝功能，IL-10，IL-12和HBV-DNA水平。结果。成熟DC和细胞因子水平的表面标志物在每组中不同; CD80，CD1A，HLA-DR和CD1a的阳性率是SDKD组中最低的。干预3个月后，CD80，CD86，CD1A，HLA-DR和IL-12的表达显着增加，而ALT，AST和IL-10在治疗组中显着降低（P <0.05）。 SDKD和SDLD组的HBV-DNA水平也显着降低（P <0.05）。结论。HBEAG阴性患者具有DCS困难患者，不同的SD综合征之间存在差异。中药干预根据综合征分化可以提高DCS的成熟和功能，提高治疗效果。

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