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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats
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Traditional Chinese Medicine Formulation Huangqi Jianzhong Tang Improves Cardiac Function after Myocardial Infarction in Rats

机译：中药制剂黄芪剑忠唐在大鼠心肌梗死后改善心脏功能

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Huangqi Jianzhong Tang (HQJZT) is a traditional Chinese herbal formula consisting of seven different herbs: Radix Astragali, Radix Paeoniae Alba, Ramulus Cinnamomi, Fructus Jujubae, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Rhizoma Zingiberis Recens, and Saccharum Granorum. The present study aims to evaluate the possible effects of HQJZT on cardiac function in acute myocardial infarction (AMI) and related mechanism. AMI model was established by ligation of the left anterior descending coronary artery followed by one-week HQJZT treatment. Survival rate was calculated. Rat heart function was assessed by heart performance analysis system. 5-Triphenyltetrazolium chloride (TTC) staining was used to observe myocardial infarct size. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining and western blot were applied to evaluate tissue apoptotic level. Treatment with high dose of HQJZT improved cardiac function, reduced infarct size, number of apoptotic cells and expression of apoptotic proteins, Bax (a proapoptotic protein), and increased expression of antiapoptotic protein, Bcl2. However, enalapril (an angiotensin-converting enzyme inhibitor) treatment did not show marked improvement of these parameters. Our present data suggest that HQJZT has potential therapeutic effects to improve cardiac function by regulation of apoptotic signaling pathway.
机译：黄芪建中唐（HQJZT）是一种由七种不同的草药组成的中草原配方：Radix Astragali，Gradix Paeoniae Alba，Raculus Cinnamomi，Fruceus Jujubae，Glycyrrhizae Radix等Rhaeparata暨Melle，Rhizoma Zingiberis再次入门，以及Saccharoma Zingiber Cash，以及Saccharoma Granorum。本研究旨在评估HQJZT对急性心肌梗死（AMI）和相关机制中心功能的影响。通过结扎左前期下降冠状动脉，然后进行一周的HQJZT治疗建立了AMI模型。计算存活率。通过心脏能分析系统评估大鼠心脏功能。 5-三苯基四唑氯化物（TTC）染色用于观察心肌梗塞尺寸。末端脱氧核苷酸转移酶介导的DUTP-BIOTIN缺口末端标记（TUNEL）染色和蛋白质印迹施用以评估组织凋亡水平。高剂量的HQJZT治疗改善了心功能，减少了梗塞大小，凋亡细胞数，凋亡蛋白的表达，Bax（促凋亡蛋白），以及抗透露蛋白，BCL2的表达增加。然而，Enalapril（血管紧张素转换酶抑制剂）处理未显示出这些参数的显着改善。我们的目前的数据表明，通过调节凋亡信号通路来改善心脏功能的HQJZT具有潜在的治疗效果。

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