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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology
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Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology

机译：基于网络药理学治疗痛风和高尿酸血症的潜在分子机制

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Background. The incidence of gout and hyperuricemia is increasing year by year in the world. Plantain is a traditional natural medicine commonly used in the treatment of gout and hyperuricemia, but the molecular mechanism of its active compounds is still unclear. Based on network pharmacology, this article predicts the targets and pathways of effective components of plantain for gout and hyperuricemia and provides effective reference for clinical medication. Method. Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP) and SymMap databases were used to screen out the active compounds and their targets in plantain. GeneCards, Therapeutic Target Database (TTD), and Online Mendelian Inheritance in Man (OMIM) databases were used to find the targets corresponding to gout and hyperuricemia. Venn diagram was used to obtain the intersection targets of plantain and diseases. The interaction network of the plantain active compounds-targets-pathways-diseases was constructed by using Cytoscape 3.7.2 software. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were carried out. Result. Seven active compounds were identified by network pharmacological analysis, including dinatin, baicalein, baicalin, sitosterol, 6-OH-luteolin, stigmasterol, and luteolin. Plantain plays a role in gout and hyperuricemia diseases by regulating various biological processes, cellular components, and molecular functions. The core targets of plantain for treating gout are MAPK1, RELA, TNF, NFKBIA, and IFNG, and the key pathways are pathways in cancer, hypoxia-inducible factor-1 (HIF-1) signaling pathway, interleukin (IL)-17 signaling pathway, Chagas disease (American trypanosomiasis), and relaxin signaling pathway. The core targets of plantain for hyperuricemia are RELA, MAPK1, NFKBIA, CASP3, CASP8, and TNF, and the main pathways are pathways in cancer, apoptosis, hepatitis B, IL-17 signaling pathway, and toxoplasmosis. Conclusion. This study explored the related targets and mechanisms of plantain for the treatment of gout and hyperuricemia from the perspective of network pharmacological analysis, reflecting the characteristics of multiple components, multiple targets, and multiple pathways, and it provides a good theoretical basis for the clinical application of plantain.
机译：背景。痛风和高尿酸血症的发病率逐年增加。植物是一种常用于治疗痛风和高尿酸血症的传统天然药物，但其活性化合物的分子机制尚不清楚。基于网络药理学，本文预测了痛风和高尿酸血症的有效成分的目标和途径，并为临床药物提供了有效参考。方法。中药系统药理学数据库和分析平台（TCMSP）和Symmap数据库用于筛选植物中的活性化合物及其目标。 Genecards，治疗目标数据库（TTD）和在Man（OMIM）数据库中的在线孟德利人继承用于找到对应于痛风和高尿血症的目标。 Venn图用于获得植物和疾病的交叉点目标。通过使用Cytoscape 3.7.2软件构建植物活性化合物 - 靶途径疾病的相互作用网络。最后，进行基因本体（GO）和京都基因组（KEGG）富集分析。结果。通过网络药理分析鉴定出七种活性化合物，包括Dinatin，Baicalind，Baicalin，谷甾醇，6-OH-叶氏菌素，Stigmasterol和Luteolin。通过调节各种生物过程，细胞组分和分子功能，植物在痛风和高尿酸血症疾病中起着作用。用于治疗痛风的植物核心靶标是MAPK1，Rela，TNF，NFKBIA和IFNG，关键途径是癌症中的途径，缺氧诱导因子-1（HIF-1）信号通路，白细胞介素（IL）-17信号传导途径，Chagas疾病（美国锥虫病）和松弛信号通道。用于高尿酸血症的核心靶标是Rela，MapK1，NFKBIA，Casp3，Casp8和TNF，主要途径是癌症，凋亡，乙型肝炎，IL-17信号传导途径和弓形虫病的途径。结论。本研究探讨了植物治疗痛风和高尿酸血症的相关目标和机制，从网络药理学分析的角度来看，反映了多种组分，多种靶标和多种途径的特征，并为临床应用提供了良好的理论基础植物。

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