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首页> 外文期刊>Genomics >Correlations of IL-23R gene polymorphism with clinicopathological characteristics and prognosis of hepatocellular carcinoma patients after interventional therapy
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Correlations of IL-23R gene polymorphism with clinicopathological characteristics and prognosis of hepatocellular carcinoma patients after interventional therapy

机译：IL-23R基因多态性与介入治疗后肝细胞癌患者临床病理特征及预后的相关性

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In this study, we summarized the association of IL-23R gene polymorphisms with hepatocellular carcinoma (HCC). A total of 270 HCC patients were selected as HCC group, and 251 healthy individuals served as the control group. PCR-RFLP was performed to detect IL-23R gene polymorphism, including rs17375018 and rs11805303. Survival rate and risk factors of HCC were identified. The findings suggested that IL-23R rs17375018 was correlated with genetic susceptibility to HCC, and GC haplotype was closely linked with the risk factors of HCC. Moreover, rs17375018 polymorphism was related to portal vein tumor thrombus (PVTT) and alcohol consumption in HCC patients, while prognosis was better in HCC patients with AA genotype of rs17375018 polymorphism. Lastly, GG genotype in rs17375018, PVTT and TNM stage III and IV were identified as independent risk factors for HCC. In conclusion, IL-23R rs17375018 polymorphism might serve as a prognostic factor in patients with HCC after interventional therapy.
机译：在这项研究中，我们总结了IL-23R基因多态性与肝细胞癌（HCC）的关联。共选出270例HCC患者作为HCC组，251名健康个体作为对照组。进行PCR-RFLP以检测IL-23R基因多态性，包括RS17375018和RS11805303。确定了HCC的存活率和危险因素。结果表明，IL-23R RS17375018与HCC的遗传易感性相关，GC单倍型与HCC的危险因素密切相关。此外，RS17375018多态性与HCC患者的门静脉肿瘤血栓（PVTT）和醇消耗有关，而HCC患者的预后患者患有17375018 rs17375018多态性的患者。最后，将GG基因型在RS17375018中，PVTT和TNM阶段III和IV鉴定为HCC的独立危险因素。总之，IL-23R RS17375018多态性可能是介入治疗后HCC患者的预后因素。

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