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首页> 外文会议>WSEAS International Conference on Environment, Ecosystems and Development >Impact of single nucleotide polymorphism of TGF-β1 gene (SNP-codon10) on hepatocellular carcinoma risk in Egyptian patients following HCV infection
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Impact of single nucleotide polymorphism of TGF-β1 gene (SNP-codon10) on hepatocellular carcinoma risk in Egyptian patients following HCV infection

机译：TGF-β1基因单核苷酸多态性（SNP-Codon10）对HCV感染后埃及患者肝细胞癌风险的影响

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TGF-β1 is a cytokine producing extracellular matrix. We evaluated TGF-β1 gene polymorphism at codon 10 and the risk of HCC in Egyptian patients with HCV infection. Quantitative determination of α1-fetoprotein, quantitative polymerase chain reaction (PCR) for HCV RNA (total viraemia) and TGF-β1 gene polymorphism was performed by the amplification refractory mutation system (ARMS-PCR). A significant difference in allelic frequency between control and HCV patients (p = 0.05). Logistic regression showed that the load of HCV-RNA is significantly predictive of the occurrence of HCC (p <0.001, OR=1.000). A significant difference of serum AFP among the three genotypes (p=0.04), particularly between CT and TT genotypic patients (p=0.01), indicating a relationship between T allele and incidence of HCC. This may enables us to determine the susceptibility to HCC among high risk groups and to provide these individuals with effective measures for early prevention or intervention.
机译：TGF-β1是一种细胞因子产生细胞外基质。我们在密码子10中评估了TGF-β1基因多态性及埃及HCV感染患者HCC的风险。通过扩增耐火突变体系（Arms-PCR）进行定量测定HCV RNA（总病毒）和TGF-β1基因多态性的定量聚合酶链式反应（PCR）和TGF-β1基因多态性。对照和HCV患者等位基因频率的显着差异（P = 0.05）。 Logistic回归显示HCV-RNA的负荷显着预测HCC的发生（P <0.001或= 1.000）。三种基因型中的血清AFP（P = 0.04）中的巨大差异，特别是CT和TT基因型患者（P = 0.01），表明T等位基因与HCC发病率之间的关系。这可能使我们能够在高风险群体中确定对HCC的易感性，并为这些个人提供有效的预防或干预的有效措施。

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