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首页> 外文期刊>Genomics >Complete genome sequence and in silico analysis of L. interrogans Canicola strain DU114: A virulent Brazilian isolate phylogenetically related to serovar Linhai
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Complete genome sequence and in silico analysis of L. interrogans Canicola strain DU114: A virulent Brazilian isolate phylogenetically related to serovar Linhai

机译：完全基因组序列和L. Interogans Canicola菌株Du114的硅分析：毒性巴西分离物与Serovar Linai的病症

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Canine leptospirosis is often caused by Leptospira interrogans serovar Canicola. Infected dogs may become asymptomatic carriers of the pathogen, which leads to many public health concerns. In this work, we present the complete genome sequencing and in silico analysis from a virulent Brazilian strain of L. interrogans serovar Canicola, previously isolated from a stray dog in Sao Paulo City. Comparative genomic analysis with a reference genome allowed identification of 1031 INDELs and several arrangement variations. Out of 35,361 SNPs identified, 6780 were missense mutations and 16,114 were synonymous mutations. The Gene Ontology terms more affected by mutations were described. Interestingly, phylogenetic analyses indicated a genetic relatedness of the isolate with serovar Linhai strain 56,609. In addition, we found several virulence-related genes and main outer membrane proteins associated with pathogenesis. This genomic information about canine isolates may help to elucidate the molecular diversity and mechanisms of Leptospira spp. pathogenicity.
机译：犬睑杆菌病通常是由Leptospira interrogans Serovar Canicola引起的。受感染的狗可能变得无症状的病原体载体，这导致许多公共卫生问题。在这项工作中，我们提出了完全基因组测序和来自L. interrogans Serovar Canicola的毒性巴西菌株的硅子分析，以前从圣保罗城的一条流浪狗隔离。比较基因组分析与参考基因组允许识别1031吲哚和几种排列变化。在鉴定的35,361个SNP中，6780名是畸形突变，16,114个是同义突变。描述了突变影响的基因本体论。有趣的是，系统发育分析表明了与Serovar Linai菌株56,609的分离物的遗传相关性。此外，我们发现几种有毒相关的基因和与发病机制相关的主要外膜蛋白。关于犬类分离物的这种基因组信息可能有助于阐明乳化物SPP的分子多样性和机制。致病性。

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