• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >A 17-marker panel for global genomic instability in breast cancer
【24h】

A 17-marker panel for global genomic instability in breast cancer

机译：17标记面板，用于乳腺癌的全球基因组不稳定性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genomic instability is a hallmark of cancer that plays a pivotal role in breast cancer development and evolution. A number of existing prognostic gene expression signatures for breast cancer are based on proliferation-related genes. Here, we identified a 17-marker panel associated with genome stability. A total of 136 primary breast carcinomas were stratified by genome stability. Matched gene expression profiles showed an innate segregation based on genome stability. We identified a 17-marker panel stratifying the training and validation cohorts into high- and low-risk patients. The 17 genes associated with genomic instability strongly impacted clinical outcome in breast cancer. Pathway analyses determined chromosome organisation, cell cycle regulation, and RNA processing as the underlying biological processes, thereby offering options for drug development and treatment tailoring. Our work supports the applicability of the 17-marker panel to improve clinical outcome prediction for breast cancer patients based on a signature accounting for genomic instability.
机译：基因组不稳定性是癌症的标志，在乳腺癌发展和演变中起着枢轴作用。乳腺癌的许多现有的预后基因表达特征是基于增殖相关基因。在这里，我们确定了一种与基因组稳定性相关的17个标记面板。通过基因组稳定性将总共136个主要乳腺癌。匹配的基因表达曲线显示了基于基因组稳定性的先天偏析。我们确定了一个17个标记面板，将培训和验证群体分解为高风险患者。与基因组不稳定相关的17个基因强烈影响乳腺癌的临床结果。途径分析确定的染色体组织，细胞周期调节和RNA加工作为潜在的生物过程，从而提供药物开发和剪裁治疗的选择。我们的工作支持17标记面板的适用性，以改善基于签名核算的乳腺癌患者的临床结果预测。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号