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首页> 外文期刊>Genomics >Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of blaCTX-M-55, blaNDM-5 and blaIMI-1, along with sophisticated iron acquisition strategies
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Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of blaCTX-M-55, blaNDM-5 and blaIMI-1, along with sophisticated iron acquisition strategies

机译：肠杆菌的人口结构和Pangenome分析肠杆菌爆发爆发的Blactx-M-55，Blandm-5和Blaimi-1，以及复杂的铁采集策略

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Enterobacter bugandensis is a recently described species that has been largely associated with nosocomial infections. We report the genome of a non-clinical E. bugandensis strain, which was integrated with publicly available genomes to study the pangenome and general population structure of E. bugandensis. Core- and whole-genome multilocus sequence typing allowed the detection of five E. bugandensis phylogroups (PG-A to E), which contain important antimicrobial resistance and virulence determinants. We uncovered several extended-spectrum β-lactamases, including blaCTX-M-55 and blaNDM-5, present in an IncX replicon type plasmid, described here for the first time in E. bugandensis. Genetic context analysis of blaNDM-5 revealed the resemblance of this plasmid with other IncX plasmids from other bacteria from the same country. Three distinctive siderophore producing operons were found in E. bugandensis: enterobactin (ent), aerobactin (iuc/iut), and salmochelin (iro). Our findings provide novel insights on the lifestyle, physiology, antimicrobial, and virulence profiles of E. bugandensis.
机译：肠杆菌Bugandensis是最近描述的物种，其在很大程度上与医院感染有关。我们报告了非临床E. Bugandensis菌株的基因组，其与公共可用的基因组相结合，研究了E. Bugandensis的Pangenome和一般人群结构。核心和全基因组多层序列序列允许检测五种Bugandensis植物（PG-A至E），其含有重要的抗微生物抗性和毒力决定簇。我们发现了几种扩展光谱β-内酰胺酶，包括在INCX复制子式质粒中存在的Blactx-M-55和Blandm-5，其中在E. Bugandensis中首次描述。 Blandm-5的遗传背景分析揭示了这种质粒与来自同一国家的其他细菌的其他Incx质粒相似。在E. Bugandensis中发现了三个独特的阳光生产记录：Enterobactin（ENT），Aerobactin（IUC / IUT）和Salmochelin（IRO）。我们的调查结果为E. Bugandensis的生活方式，生理学，抗微生物和毒力分布提供了新的见解。

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