Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of bla(CTX-M-55), bla(NDM-5) and bla(IMI-1), along with sophisticated iron acquisition strategies

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Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of bla(CTX-M-55), bla(NDM-5) and bla(IMI-1), along with sophisticated iron acquisition strategies

机译：肠杆菌的人口结构和Pangenome分析肠杆菌突发出BLA（CTX-M-55），BLA（NDM-5）和BLA（IMI-1）的存在，以及复杂的铁采集策略

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Enterobacter bugandensis is a recently described species that has been largely associated with nosocomial infections. We report the genome of a non-clinical E. bugandensis strain, which was integrated with publicly available genomes to study the pangenome and general population structure of E. bugandensis. Core- and whole-genome multilocus sequence typing allowed the detection of five E. bugandensis phylogroups (PG-A to E), which contain important antimicrobial resistance and virulence determinants. We uncovered several extended-spectrum beta-lactamases, including bla(CTX-M-55) and bla(NDM-5), present in an IncX replicon type plasmid, described here for the first time in E. bugandensis. Genetic context analysis of bla(NDM-)(5) revealed the resemblance of this plasmid with other IncX plasmids from other bacteria from the same country. Three distinctive siderophore producing operons were found in E. bugandensis: enterobactin (ent), aerobactin (iuc/iut), and salmochelin (iro). Our findings provide novel insights on the lifestyle, physiology, antimicrobial, and virulence profiles of E. bugandensis.

机译：肠杆菌Bugandensis是最近描述的物种，其在很大程度上与医院感染有关。我们报告了非临床E. Bugandensis菌株的基因组，其与公共可用的基因组集成，以研究E. Bugandensis的Pangenome和一般人群结构。核心和全基因组多层序列序列允许检测5e.Bugandensis的植物群（PG-A至E），其含有重要的抗微生物抗性和毒力决定簇。我们发现了几种扩展光谱β-内酰胺酶，包括在INCX复制子式质粒中存在的BLA（CTX-M-55）和BLA（NDM-5），这是在E. Bugandensis中首次描述的。 BLA（NDM - ）（5）的遗传背景分析揭示了这种质粒与来自同一国家的其他细菌的其他Incx质粒相似。在E. Bugandensis中发现了三个独特的阳光生产记录：Enterobactin（ENT），Aerobactin（IUC / IUT）和Salmochelin（IRO）。我们的研究结果提供了关于E. Bugandensis的生活方式，生理学，抗菌药物和毒力分布的新颖见解。

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《Genomics》 |2020年第2期|共10页
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正文语种 eng
中图分类医学遗传学;
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Core genome; Drug resistance; Virulence; Beta-lactamase; Genomic island;

机译：核心基因组;耐药;毒力;β-内酰胺酶;基因组岛;

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1. Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of bla(CTX-M-55), bla(NDM-5) and bla(IMI-1), along with sophisticated iron acquisition strategies [J] . Genomics . 2020,第2期

机译：肠杆菌的人口结构和Pangenome分析肠杆菌突发出BLA（CTX-M-55），BLA（NDM-5）和BLA（IMI-1）的存在，以及复杂的铁采集策略
2. Salmonella enterica serovar Typhimurium ST34 co-expressing bla_NDM-5 and bla_CTX-M-55 isolated in China [J] . Lang Yang, Xiaofeng Hu, Xuebin Xu, Emerging microbes & infections. . 2017,第7期

机译：共表达 bla _{NDM-5 和 bla _{CTX-M-55的肠炎沙门氏菌鼠伤寒沙门氏菌ST34 在中国隔离}}
3. Acquisition of a High Diversity of Bacteria during the Hajj Pilgrimage, Including Acinetobacter baumannii with bla(OXA-72) and Escherichia coli with bla(NDM-5) Carbapenemase Genes [J] . Leangapichart Thongpan, Gautret Philippe, Griffiths Karolina, Antimicrobial agents and chemotherapy. . 2016,第10期

机译：在朝j朝圣期间获得高度多样性的细菌，包括鲍曼不动杆菌与bla（OXA-72）和大肠杆菌与bla（NDM-5）碳青霉烯酶基因
4. Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of blaCTX-M-55, blaNDM-5 and blaIMI-1, along with sophisticated iron acquisition strategies [O] . Filipe P. Matteoli, Hemanoel Passarelli-Araujo, Francisnei Pedrosa-Silva, 2020

机译：肠杆菌的人口结构和Pangenome分析肠杆菌爆发爆发的Blactx-M-55，Blandm-5和Blaimi-1，以及复杂的铁采集策略

Population structure and pangenome analysis of Enterobacter bugandensis uncover the presence of bla(CTX-M-55), bla(NDM-5) and bla(IMI-1), along with sophisticated iron acquisition strategies

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